Titlebook: Neuroglia in Neurodegenerative Diseases; Alexei Verkhratsky,Margaret S. Ho,Vladimir Parpura Book 2019 Springer Nature Singapore Pte Ltd. 2

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,Oligodendroglial Cells in Alzheimer’s Disease,of the human brain. Oligodendrocytes and myelin also provide metabolic and trophic support for axons and their disruption results in axonal demise and neurodegeneration, which are key features of Alzheimer’s disease (AD). Notably, the brain has a remarkable capacity for regenerating oligodendrocytes

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,Microglia in Parkinson’s Disease,ns in physiological and pathological conditions. Physiologically, microglia mediate synaptic pruning and remodeling crucial for neural circuits and brain connectivity. In pathological conditions such as neurodegeneration in the Parkinson’s disease (PD), microglia are activated, migrated to the injur

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,Astrocytes in Huntington’s Disease,ed by a polyglutamine repeat expansion mutation in the widely expressed HTT protein. The clinical manifestations of HD have been largely attributed to the neurodegeneration of specific neuronal cell types in the brain. However, it has become clear that other cell types, including astrocytes, play im

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Neuroglia in Ageing,n. This reduces glial ability to homeostatically nurture, protect and regenerate the nervous tissue. Such neuroglial paralysis also facilitates neurodegenerative processes. Ageing of neuroglia is variable and can be affected by environmental factors and comorbidities.

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