Titlebook: Neurogenetics; Current Topics in Ce Boris Egger Textbook 2023 Springer Nature Switzerland AG 2023 Neurogenesis.Organoids.Animal Models.Neur

Pessary

Early Neurogenesis and Gliogenesis in ,,ed and specified in a spatio-temporal manner in the developing . embryo. The relevance of symmetric versus asymmetric stem cell divisions will be conveyed and the major genetic pathway controlling embryonic neurogenesis will be introduced.

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Models of Neurodegenerative Diseases,s. However, failure to translate potential therapeutic findings from bench to bedside is primarily due to limitations of animal models and needs urgent attention. In this chapter, we discuss different neurodegenerative diseases and compare the different models commonly used in their study.

prosperity

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Neural Stem Cells and Brain Tumour Models in ,,ool. We will learn that different division modes will lead to vastly different outcomes in terms of the generated cell lineage size. The different neural precursor types use also different timings and cellular mechanisms to terminate proliferation once the correct number of progeny cells is reached.

archetype

Evolution and Origins of Nervous Systems, regarding the origin of neurons in early-branching metazoans as well as in some unicellular organisms. We describe the current knowledge about the organization and the unsuspected complexity of nerve nets in Cnidaria and highlight some of the current hypotheses about the centralization of nervous system in Bilateria.

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Embryonic Neurogenesis in the Mammalian Brain,tions to distinguish higher evolved gyrencephalic from more primitive lissencephalic brains. We discuss the concepts and cellular mechanisms that might have led to neocortex expansion during evolution toward the primate brain.