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Titlebook: Neuroblastoma; Discoveries and Chal Shahab Asgharzadeh,Frank Westermann Book 2024 Springer Nature Switzerland AG 2024 Sympathetic nervous s

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书目名称Neuroblastoma
副标题Discoveries and Chal
编辑Shahab Asgharzadeh,Frank Westermann
视频video
概述Provides a synopsis of current clinical and basic research on neuroblastoma.Presents the state of the art regarding tumor microenvironment and targeted therapeutics such as immunotherapy.Edited and au
丛书名称Pediatric Oncology
图书封面Titlebook: Neuroblastoma; Discoveries and Chal Shahab Asgharzadeh,Frank Westermann Book 2024 Springer Nature Switzerland AG 2024 Sympathetic nervous s
描述.This book provides a state-of-the-art review of the biology, treatment, and other critical aspects of neuroblastoma, reflecting the dramatic advances that have been achieved in understanding and management. Topics are arranged according to the book’s dominant themes of the “seed” (tumor genomics, epigenetics, metabolism, and stem cells) and the “soil” (tumor microenvironment, adaptive and innate immunity, and exosomes) and how both of these influences can serve as rich targets for intervention, whether by targeted molecular therapy or immunotherapy. Therapeutic strategies that are currently in use or under consideration for the future are discussed in detail, with the focus on precision medicine. Further individual chapters are devoted to the biology and genetics of relapsed/refractory neuroblastoma and emerging methods of evaluating tumor burden. Finally, in keeping with the, albeit modest, increase in cure rates in high-risk disease, immune and cellular therapies are reviewed. This coverage of what is becoming a not-so-enigmatic tumor will appeal to a broad readership including both experimental oncologists and clinicians who care for patients with neuroblastoma..
出版日期Book 2024
关键词Sympathetic nervous system tumors; Childhood tumor genomics and epigenetics; Pediatric precision medic
版次1
doihttps://doi.org/10.1007/978-3-031-51292-6
isbn_softcover978-3-031-51294-0
isbn_ebook978-3-031-51292-6Series ISSN 1613-5318 Series E-ISSN 2191-0812
issn_series 1613-5318
copyrightSpringer Nature Switzerland AG 2024
The information of publication is updating

书目名称Neuroblastoma影响因子(影响力)




书目名称Neuroblastoma影响因子(影响力)学科排名




书目名称Neuroblastoma网络公开度




书目名称Neuroblastoma网络公开度学科排名




书目名称Neuroblastoma被引频次




书目名称Neuroblastoma被引频次学科排名




书目名称Neuroblastoma年度引用




书目名称Neuroblastoma年度引用学科排名




书目名称Neuroblastoma读者反馈




书目名称Neuroblastoma读者反馈学科排名




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Genetic Predisposition,ity and also tumor aggressiveness. More recently, sequencing studies of germline DNA obtained from children diagnosed with neuroblastoma have revealed rare variants in known cancer predisposition genes that may contribute to neuroblastoma susceptibility and are predicted to have larger effect size.
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The Genetic Basis of the Divergent Clinical Courses in Neuroblastoma,st, such alterations are invariably lacking in low-risk neuroblastoma, suggesting that absence of telomere maintenance and consecutive lack of cellular immortality may cause spontaneous regression and differentiation. In addition, oncogenic mutations have been found in the gene ., encoding for a rec
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