Titlebook: Nephrotoxic Mechanisms of Drugs and Environmental Toxins; George A. Porter Book 1982 Springer Science+Business Media New York 1982 Ketone.

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Aminoglycoside Nephrotoxicity, are lightly bound to plasma proteins, and are not metabolized in the body. In view of their very wide antibacterial spectrum, aminoglycosides are an important class of antimicrobial agents. Although they are oto- and nephrotoxic, these agents are commonly used in clinical treatment.

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Aminoglycoside Interactions with Other Drugsently implicated. Such drugs include chemotherapeutic agents, anesthetics, and several antimicrobial agents. Not infrequently, patients who are critically ill receive one or more potentially nephrotoxic drugs during the course of aminoglycoside therapy. Thus attention has been directed to the possib

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Nephrotoxicity of Cephalosporin Antibioticstoxicity varies considerably among the individual cephalosporins. As recently reviewed in a clinical context (Prime and Tune, 1981), toxicity is severe enough with some to restrict their use significantly, but ranges from relatively mild to absent with others (Tune and Fravert, 1980b). The reasons f

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