Titlebook: Narcotic Drugs; Biochemical Pharmaco Doris H. Clouet Book 1971 Plenum Press, New York 1971 Calcium.DNA.RNA.amino acid.bacteria.biochemistry

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Catecholamines and 5-Hydroxytryptamineises are the natural consequences of the facts that the amines have a ubiquitous, although sometimes specialized, distribution in the central nervous system that often can be affected by drugs and that certain of these amines have been established to play key roles in the peripheral nervous system a

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Acetylcholine and Cholinesterase, a number of studies have been made on the effect of morphine on the concentration of this amine in the brain. Giarman and Pepeu. found that morphine (50 mg/kg), which produced severe depression in rats, raised the acetylcholine content of the brain by 47 %. This effect was shared by the general de

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Corticosteroid Hormonesof chronic morphine administration to cause hypertrophy of the adrenal gland was first reported by McKay and McKay. and subsequently confirmed by other investigators.. Morphine was used by Selye. to first evoke an alarm reaction and its attendant increase in the adrenal cortical response. In additio

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Single Cells It has proved exceedingly useful for the elucidation of a variety of phenomena, including complex metabolic pathways and cycles and, more recently, mechanisms by which cells regulate the rate of metabolic processes. This approach suffers from the drawback of any model, namely, the uncertainty about

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The Kidneyonses to narcotic analgesics and at the same time excretes these drugs and their metabolites. Studies are described in which investigators have attempted to relate mechanisms of development of tolerance to the effects of narcotics on renal function. If it is assumed for heuristic purposes that the a

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