Titlebook: NATO in the Post-Cold War Era; Continuity and Trans Massimo de Leonardis Book 2023 The Editor(s) (if applicable) and The Author(s), under e

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Alan P. Dobsonypes of human cancers. Furthermore, DUSP3 has other biological functions involving immune response mediation, thrombosis, hemostasis, angiogenesis, and genomic stability that occur through either MAPK-dependent or MAPK-independent mechanisms. This broad spectrum of actions is likely due to the large

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Luca Ratti,Alessandro Leonardi expression of target genes involved in the progression of gynecological cancers, as well as the expression of genes accountable for the development of resistance toward common chemotherapeutics and radiotherapy. The cell molecular targets implicated in curcumin’s resensitizing effect, when used tog

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Davide Borsanioptimal time of drug administration that maximizes efficacy of ACE inhibitors, while minimizing the occurrence of adverse effects. We have developed an integrated pharmacokinetic–pharmacodynamic model that adequately captures the disposition kinetics of the paradigm drug benazeprilat, as well as the

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Andrea Carati linked to mutations that cause the appearance of a non-canonical ion permeation pathway as a new pathological mechanism. This review provides an integrated overview of the biophysical properties of non-canonical pores described in voltage-dependent cation channels (K., Na., Ca., H.1, and TRPM3) and

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Jean-Sylvestre Mongrenierocesses are due not to receptor activation but to fusion or mutation of the encoding genes. A considerable panel of anti-Trk drugs, developed recently, has been investigated both in vitro and in living mice for their effects on cancer cells. Many such drugs protect from cancers by preventing cell pr

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Kris Quantenother types of agonist-stimulated cells, and we have discussed much of it in this review article. While the wealth of data in nonproliferating cells provides some indications of what mechanisms might be involved in the growth factor-induced changes in [Ca.]., it is clear that much work must be done