| 书目名称 | miRNAs and Target Genes in Breast Cancer Metastasis |
| 编辑 | Seema Sethi |
| 视频video | |
| 概述 | Addresses bone and brain metastasis in breast cancer.Uniquely exemplifies molecular alterations with clinical implications.Explains how targeting miRNAs could lead to novel therapeutic strategies?.Inc |
| 丛书名称 | SpringerBriefs in Cancer Research |
| 图书封面 |  |
| 描述 | This SpringerBrief gives the latest research on the role of miRNAs in breast cancer metastasis. MicroRNAs (miRNAs) are recently described small endogenous noncoding RNAs implicated in the posttranscriptional control of gene expression. These tiny molecules are involved in developmental, physiologic phenomenon as well as pathologic processes including cancers. In fact, miRNAs have emerged as critical regulators of cancer progression, invasion and metastasis. This is mainly because a single miRNA can affect several downstream genes and signaling pathways with oncogenic or tumor suppressor actions depending on the target genes affected. Due to this multimodal downstream signaling effects, these small endogenous molecules hold great promise in metastasis prevention and treatment. Modulating the activity of miRNAs can provide opportunities for novel cancer interventions. Targeting miRNAs could become a novel prognostic and therapeutic strategy to prevent the future development of metastasis. Thus, miRNAs could also serve as a potential targets for anti-metastatic therapy. The book explores how the expression of miRNAs in the primary tumor could be silenced using antagomirs (chemically |
| 出版日期 | Book 2014 |
| 关键词 | antagomirs; bone metastasis; brain metastasis; miRNA mimetic; microRNAs; gene expression |
| 版次 | 1 |
| doi | https://doi.org/10.1007/978-3-319-08162-5 |
| isbn_softcover | 978-3-319-08161-8 |
| isbn_ebook | 978-3-319-08162-5Series ISSN 2194-1173 Series E-ISSN 2194-1181 |
| issn_series | 2194-1173 |
| copyright | Springer International Publishing Switzerland 2014 |
发表于 2025-3-21 16:16:45
