| 书目名称 | Myocardial Ischemia | | 副标题 | Proceedings of a Sat | | 编辑 | Naranjan S. Dhalla,Ian R. Innes,Robert E. Beamish | | 视频video | | | 丛书名称 | Developments in Cardiovascular Medicine | | 图书封面 |  | | 描述 | Whenever the coronary flow is inadequate to provide enough oxygen to meet the energy demands of the tissue, the heart becomes ischemic. Manifestations of myocardial ischemia include depression in contractile activity, changes in metabolic pattern, abnormalities in ultrastructure, and alterations in membrane potential. Ischemic changes during the early phase are reversible but as the period of ischemia is extended, the injury becomes irreversible. The transition from reversible to irreversible ischemic injury is usually associated with some membrane defects. It is worthwhile to consider that the irreversible damage to the ischemic myocardium occurs when the sarcolemmal membrane is altered in suoh a way that it would promote 2 a net gain of ca + in the cardiac cell upon reinstitution of blood flow. Suoh a lesion could result when mechanisms for the entry as well as removal 2 of ca + from the myocardial oell become defective. In this regard, 2 depression of the sarcolemmal ca + pump would favour the oocurrenoe of 2 intracellular ca + overload. Furthermore, inhibition of the Na+-K+ pump would lead to elevation of myoplasmic Na+ which oould then increase the 2 2 intracellular concentrat | | 出版日期 | Conference proceedings 1987 | | 关键词 | arrhythmia; artery; atherosclerosis; blood; cardiovascular; cell; depression; drugs; energy; heart; heart dise | | 版次 | 1 | | doi | https://doi.org/10.1007/978-1-4613-2055-5 | | isbn_softcover | 978-1-4612-9221-0 | | isbn_ebook | 978-1-4613-2055-5Series ISSN 0166-9842 | | issn_series | 0166-9842 | | copyright | Springer Science+Business Media Dordrecht 1987 |
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发表于 2025-3-21 16:06:17
