| 书目名称 | Myeloid-Derived Suppressor Cells and Cancer |
| 编辑 | David Escors,James E. Talmadge,Grazyna Kochan |
| 视频video | |
| 概述 | Comprehensively explores the biology and role of MDSCs in cancer.Covers therapeutic targeting via the STAT3 pathway, a major regulatory pathway in MDSCs functions as well as in tumour cells.Particular |
| 丛书名称 | SpringerBriefs in Immunology |
| 图书封面 |  |
| 描述 | The book starts with an introduction to and history of myeloid-derived suppressor cells (MDSCs), followed by a description of their differentiation, their role in the tumour microenvironment and their therapeutic targeting. It closes with an outlook on future developments. In cancer patients, myelopoiesis is perturbed and instead of generating immunogenic myeloid cells (such as dendritic cells, inflammatory macrophages and granulocytes), there is an increase in highly immature MDSCs. These cells are distributed systemically, resulting in general immunosuppression. They also infiltrate tumours, promoting their progression and metastasis by inhibiting the natural anti-tumour immune response. As these cells also interact with classical anti-neoplastic treatments, they have become major therapeutic targets in the pharmaceutical industry and in oncology research.. |
| 出版日期 | Book 2016 |
| 关键词 | Ex vivo MDSC Differentiation; STAT3 Pathway; Human and Mouse MDSCs; Murine MDSC Differentiation; Myeloid |
| 版次 | 1 |
| doi | https://doi.org/10.1007/978-3-319-26821-7 |
| isbn_softcover | 978-3-319-26819-4 |
| isbn_ebook | 978-3-319-26821-7Series ISSN 2194-2773 Series E-ISSN 2194-2781 |
| issn_series | 2194-2773 |
| copyright | The Author(s) 2016 |
发表于 2025-3-21 18:29:19
