| 书目名称 | Mucosal Vaccines |
| 副标题 | Modern Concepts, Str |
| 编辑 | Pamela A. Kozlowski |
| 视频video | http://file.papertrans.cn/640/639838/639838.mp4 |
| 概述 | Includes supplementary material: |
| 丛书名称 | Current Topics in Microbiology and Immunology |
| 图书封面 |  |
| 描述 | .This volume is focused on the development of vaccines which generate immune effectors capable of blocking mucosal entry or peripheral pathogen spread. A critical first step in the design of mucosal vaccines is the selection of administration route. Not all mucosal immunization routes are created equally when it comes to eliciting immune responses in multiple body compartments. This subject and situations when a mucosal route may not be required for vaccine delivery are reviewed here with an emphasis on the sublingual immunization route, which may offer a safer alternative to the nasal route for induction of broadly disseminated immune responses. External host defenses that inhibit entry of microorganisms at mucosal surfaces also pose obstacles to the efficient internalization of mucosally-applied vaccines. Transcutaneous immunization with appropriate adjuvants and permeation enhancers can induce mucosal immune responses and may be advantageous for bypassing these luminal barriers. Other chapters describe strategies for enhancing uptake of mucosal vaccines, for instance through targeted delivery to antigen-sampling M cells, construction of virus-like particles which mimic natural p |
| 出版日期 | Book 2012 |
| 关键词 | CD4+T helper cells; biothreat agents; dry powder vaccines; mucosal immune responses; particle-based muco |
| 版次 | 1 |
| doi | https://doi.org/10.1007/978-3-642-23693-8 |
| isbn_softcover | 978-3-642-43923-0 |
| isbn_ebook | 978-3-642-23693-8Series ISSN 0070-217X Series E-ISSN 2196-9965 |
| issn_series | 0070-217X |
| copyright | The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer-Verlag GmbH, DE |
|Archiver|手机版|小黑屋|
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