| 书目名称 | Mosaicism in Human Skin | | 副标题 | Understanding Nevi, | | 编辑 | Rudolf Happle,Antonio Torrelo | | 视频video | | | 概述 | Unique book focused on skin mosaicism, and underlying molecular mechanisms of skin disorders.Reader-friendly, richly illustrated and clearly structured, for experienced dermatologists and residents in | | 图书封面 |  | | 描述 | .This second edition offers a fully revised and updated work on a rapidly growing field of knowledge, and was prepared by two experts whose goal was to explain the molecular basis of mosaic skin disorders in a language that is accessible for practicing physicians and medical students alike. It presents a timely and comprehensive overview of the strikingly manifold patterns and peculiarities of mosaic skin disorders in a straightforward, reader-friendly way that will help physicians to further improve genetic counseling and treatment outcomes..The first two parts of the book are devoted to the mechanisms and patterns of cutaneous mosaicism, and include an explanation of genomic and epigenetic mosaicism and a description of the archetypical segmental patterns including the lines of Blaschko and the flag-like, phylloid and lateralization pattern, the non-segmental pattern of large congenital melanocytic nevi, and the sash-like arrangement as noted in a particular type of cutis tricolor. The concept of lethal mutations surviving as mosaics has now been confirmed by molecular analysis in many sporadically occurring phenotypes. The difference between monoallelic and biallelic traits has | | 出版日期 | Book 2023Latest edition | | 关键词 | Genetics; Lethal mutations; Lines of Blaschko; Nevi; Skin disorders; Patterns of segmental mosaicism; Type | | 版次 | 2 | | doi | https://doi.org/10.1007/978-3-030-89937-0 | | isbn_softcover | 978-3-030-89939-4 | | isbn_ebook | 978-3-030-89937-0 | | copyright | Springer Nature Switzerland AG 2023 |
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发表于 2025-3-21 17:56:02
