| 书目名称 | Molecular mechanisms and physiology of disease |
| 副标题 | Implications for Epi |
| 编辑 | Nilanjana Maulik,Tom Karagiannis |
| 视频video | |
| 概述 | Includes chapters written by leading experts in the field.Examines major diseases (cardiovascular disease, respiratory disease, diabetes, cancer) from a molecular and physiological perspective.Include |
| 图书封面 |  |
| 描述 | .In a simplified form, epigenetics refers to heritable changes in phenotype that are not due to changes in the underlying DNA sequence. In this book, epigenetic mechanisms of regulation and dysregulation in health and disease are explored in great depth. Detailed chapters on epigenetic processes including DNA methylation and chromatin post-translational modifications including potential interventions with DNA methyltransferase inhibitors and histone deacetylase inhibitors are explored in initial chapters. These provide a detailed overview and important background to the entire field. The book is then focussed on epigenetic mechanisms involved in various diseases including anti-inflammatory and autoimmune conditions. Important accounts relating to the effects of epigenetics in metabolic syndrome, cardiovascular disease and asthma are the focus of subsequent chapters. The role of epigenetic dysregulation in malignancy is a current topic of interest and represents an intense field of research. A large component of this book is dedicated to the analysis of aberrant epigenetic processes in carcinogenesis and cancer progression. Further, chapters are focused on emerging cancer prevention |
| 出版日期 | Book 2014 |
| 关键词 | DNA methylation; developmental origins of disease; histone acetylation; histone methylation; molecular m |
| 版次 | 1 |
| doi | https://doi.org/10.1007/978-1-4939-0706-9 |
| isbn_softcover | 978-1-4939-4623-5 |
| isbn_ebook | 978-1-4939-0706-9 |
| copyright | Springer Science+Business Media New York 2014 |
发表于 2025-3-21 17:03:05
