| 书目名称 | Molecular Mechanisms of Notch Signaling |
| 编辑 | Tilman Borggrefe,Benedetto Daniele Giaimo |
| 视频video | |
| 概述 | Provides the most recent overview of Notch signal transduction.Is an in-depth introduction into molecular mechanisms of signal transduction exemplified by the Notch signaling pathway.Covers topics suc |
| 丛书名称 | Advances in Experimental Medicine and Biology |
| 图书封面 |  |
| 描述 | .This book describes the Notch signaling pathway with a focus on molecular mechanisms. The Notch signaling pathway is a seemingly simple pathway that does not involve any second messenger. Upon ligand binding two consecutive proteolytic cleavages of the NOTCH receptor release the Notch intracellular domain from the membrane. The Notch intracellular domain migrates into the nucleus and activates gene expression. .Recently, new technologies allowed us to better understand this pivotal signaling cascade and revealed new regulatory mechanisms. The different chapters cover many aspects of the Notch signaling focusing on the mechanisms governing the receptor/ligand interaction as well as on the downstream intracellular signaling events. Aspects of both canonical and non-canonical signaling are discussed and the function of Notch signaling in physiological and pathological contexts are elucidated.. .This book is not only intended for experts but it should also be a usefulresource for young, sprouting scientists or interested scientists from other research areas, who may use this book as a stimulating starting point for further discoveries and developments.. |
| 出版日期 | Book 2018 |
| 关键词 | Notch Receptor/ligand interaction; Endosomal trafficking of the Notch Receptor; Epigenetic Regulation |
| 版次 | 1 |
| doi | https://doi.org/10.1007/978-3-319-89512-3 |
| isbn_softcover | 978-3-030-07789-1 |
| isbn_ebook | 978-3-319-89512-3Series ISSN 0065-2598 Series E-ISSN 2214-8019 |
| issn_series | 0065-2598 |
| copyright | Springer International Publishing AG, part of Springer Nature 2018 |
发表于 2025-3-21 16:56:52
