| 书目名称 | Modulating Gene Expression by Antisense Oligonucleotides to Understand Neural Functioning | | 编辑 | Margaret M. McCarthy | | 视频video | | | 丛书名称 | Perspectives in Antisense Science | | 图书封面 |  | | 描述 | When first introduced, antisense oligonucleotides were hailedas the long awaited magic bullet that would provide an unprecedentedlevel of specificity in controlling gene expression. Following thisinitial enthusiasm, antisense oligonucleotides have been maligned asnonspecific, toxic, and essentially useless. However, application ofantisense oligonucleotide technology in the nervous system standsapart from the use of this technique in peripheral systems, largelybecause of its enormous success. The source of this success remains amatter of some controversy...Modulating Gene Expression by Antisense Oligonucleotides toUnderstand. .Neural Functioning. addresses the origins of thatcontroversy and determines whether the nervous system is a privilegedsite for antisense oligonucleotide action and not subject to the samevagaries and pitfalls as non-neuronal systems. ..Modulating Gene Expression by Antisense Oligonucleotides toUnderstand. .Neural Functioning. contains chapters by experts inthe field that focus on the use of this technique in a variety ofbehavioral systems, as well as rapid and nonspecific effects and theuptake and metabolism of antisense oligonucleotides by the nervoussystem. | | 出版日期 | Book 1998 | | 关键词 | Nervous System; Nucleotide; RNA; gene expression; metabolism | | 版次 | 1 | | doi | https://doi.org/10.1007/978-1-4615-4933-8 | | isbn_softcover | 978-1-4613-7238-7 | | isbn_ebook | 978-1-4615-4933-8Series ISSN 1566-0389 | | issn_series | 1566-0389 | | copyright | Springer Science+Business Media New York 1998 |
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