| 书目名称 | Modified Nucleic Acids in Biology and Medicine |
| 编辑 | Stefan Jurga,Volker A. Erdmann (Deceased),Jan Barc |
| 视频video | |
| 概述 | Solves problems in the analysis of structure and functions of genetic material.Equips readers to handle complex diagnostic methods.Covers different applications of nucleic acids |
| 丛书名称 | RNA Technologies |
| 图书封面 |  |
| 描述 | .This volume is comprised of 18 chapters, covering various aspects of DNA modification and RNA modified bases. It also discusses in detail circular RNA, therapeutic oligonucleotides and their different properties...The chemical nature of DNA, RNA, protein and lipids makes these macromolecules easily modifiable, but they are also susceptible to damage from both endogenous and exogenous agents. Alkylation and oxidation show a potential to disrupt the cellular redox equilibrium and cause cellular damage leading to inflammation and even chronic disease. Furthermore, DNA damage can drive mutagenesis and the resulting DNA sequence changes can induce carcinogenesis and cancer progression...Modified nucleosides can occur as a result of oxidative DNA damage and RNA turnover, and are used as markers for various diseases. To function properly some RNA needs to be chemically modified post-transcriptionally. Dysregulation of the RNA-modification pattern or of the levelsof the enzymes that catalyze these modifications alters RNA functionality and can result in complex phenotypes, likely due to defects in protein translation. While modifications are best characterized in noncoding ribonucleic aci |
| 出版日期 | Book 2016 |
| 关键词 | RNA and DNA acids; biomarkers; modified nucleic acids; molecular diagnostics; nucleic acid biological c |
| 版次 | 1 |
| doi | https://doi.org/10.1007/978-3-319-34175-0 |
| isbn_softcover | 978-3-319-81693-7 |
| isbn_ebook | 978-3-319-34175-0Series ISSN 2197-9731 Series E-ISSN 2197-9758 |
| issn_series | 2197-9731 |
| copyright | Springer International Publishing Switzerland 2016 |
发表于 2025-3-21 17:31:59
