| 书目名称 | Modern Dose-Finding Designs for Cancer Phase I Trials: Drug Combinations and Molecularly Targeted Ag |
| 编辑 | Akihiro Hirakawa,Hiroyuki Sato,Shigeyuki Matsui |
| 视频video | |
| 概述 | Focuses on the two advanced areas of adaptive model-based dose-finding methods for phase I trials with multiple drugs/outcomes in oncology and other fields.Provides software implementations to facilit |
| 丛书名称 | SpringerBriefs in Statistics |
| 图书封面 |  |
| 描述 | This book deals with advanced methods for adaptive phase I dose-finding clinical trials for combination of two agents and molecularly targeted agents (MTAs) in oncology. It provides not only methodological aspects of the dose-finding methods, but also software implementations and practical considerations in applying these complex methods to real cancer clinical trials. Thus, the book aims to furnish researchers in biostatistics and statistical science with a good summary of recent developments of adaptive dose-finding methods as well as providing practitioners in biostatistics and clinical investigators with advanced materials for designing, conducting, monitoring, and analyzing adaptive dose-finding trials. The topics in the book are mainly related to cancer clinical trials, but many of those topics are potentially applicable or can be extended to trials for other diseases. The focus is mainly on model-based dose-finding methods for two kinds of phase I trials. One is clinical trials with combinations of two agents. Development of dose-finding methods for two-agent combination trials requires reasonable models that can adequately capture joint toxicity probabilities for two agents |
| 出版日期 | Book 2018 |
| 关键词 | Adaptive Design; Cancer; Dose Finding; Phase I; Phase I/II |
| 版次 | 1 |
| doi | https://doi.org/10.1007/978-4-431-55573-5 |
| isbn_softcover | 978-4-431-55572-8 |
| isbn_ebook | 978-4-431-55573-5Series ISSN 2191-544X Series E-ISSN 2191-5458 |
| issn_series | 2191-544X |
| copyright | The Author(s) 2018 |
发表于 2025-3-21 19:15:37
