| 书目名称 | Modelling Proteasome Dynamics in a Bayesian Framework |
| 编辑 | Sabine Stübler |
| 视频video | |
| 概述 | A study in systems biology, immunology and cell biology |
| 丛书名称 | BestMasters |
| 图书封面 |  |
| 描述 | .Sabine Stübler compares different proteasome isoforms and subtypes in terms of their transport and active site-related parameters applying an existing computational model. In a second step, the author extends this model to be able to describe the influence of proteasome inhibitors in .in vitro .experiments. The computational model, which describes the hydrolysis of short fluorogenic peptides by the 20S proteasome, is calibrated to experimental data from different proteasome isoforms using an approximate Bayesian computation approach. The dynamics of proteasome inhibitors are included into the model in order to demonstrate how to modulate the inhibitor’s transport parameters for strong or isoform-specific inhibition.. |
| 出版日期 | Book 2017 |
| 关键词 | Approximate Bayesian Computation; ODE Model; Thymoproteasome; Immunoproteasome; Proteaseome inhibitor; En |
| 版次 | 1 |
| doi | https://doi.org/10.1007/978-3-658-20167-8 |
| isbn_softcover | 978-3-658-20166-1 |
| isbn_ebook | 978-3-658-20167-8Series ISSN 2625-3577 Series E-ISSN 2625-3615 |
| issn_series | 2625-3577 |
| copyright | The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Fachmedien Wies |
发表于 2025-3-21 19:41:40
