| 书目名称 | Modeling Dose-Response Microarray Data in Early Drug Development Experiments Using R |
| 副标题 | Order-Restricted Ana |
| 编辑 | Dan Lin,Ziv Shkedy,Luc Bijnens |
| 视频video | |
| 概述 | This book focuses on the analysis of microarray data in the dose-response setting in early drug development experiments in the pharmaceutical industry.Part I discusses the dose-response setting and th |
| 丛书名称 | Use R! |
| 图书封面 |  |
| 描述 | .This book focuses on the analysis of dose-response microarray data in pharmaceutical settings, the goal being to cover this important topic for early drug development experiments and to provide user-friendly R packages that can be used to analyze this data. It is intended for biostatisticians and bioinformaticians in the pharmaceutical industry, biologists, and biostatistics/bioinformatics graduate students..Part I of the book is an introduction, in which we discuss the dose-response setting and the problem of estimating normal means under order restrictions. In particular, we discuss the pooled-adjacent-violator (PAV) algorithm and isotonic regression, as well as inference under order restrictions and non-linear parametric models, which are used in the second part of the book..Part II is the core of the book, in which we focus on the analysis of dose-response microarray data. Methodological topics discussed include:.• Multiplicity adjustment.• Test statistics and procedures for the analysis of dose-response microarray data.• Resampling-based inference and use of the SAM method for small-variance genes in the data.• Identification an |
| 出版日期 | Book 2012 |
| 关键词 | Dose-response microarray data; Estimation and inference under order restrictions; Gene expression; R |
| 版次 | 1 |
| doi | https://doi.org/10.1007/978-3-642-24007-2 |
| isbn_softcover | 978-3-642-24006-5 |
| isbn_ebook | 978-3-642-24007-2Series ISSN 2197-5736 Series E-ISSN 2197-5744 |
| issn_series | 2197-5736 |
| copyright | Springer-Verlag Berlin Heidelberg 2012 |
发表于 2025-3-21 17:45:43
