| 书目名称 | Mitosis |
| 副标题 | Methods and Protocol |
| 编辑 | David J. Sharp |
| 视频video | |
| 概述 | Presents current up-to-date methodologies.Provides step-by-step detail essential for reproducible results.Contains key notes and implementation advice from the experts.Includes supplementary material: |
| 丛书名称 | Methods in Molecular Biology |
| 图书封面 |  |
| 描述 | .Mitosis: Methods and Protocols. provides state-of-the-art overviews on the most important approaches currently used in mitosis research spanning from the analysis of single molecules in isolation to their utilization within the complex environment of the cell. The volume is divided into four parts, each focused on methods pertaining to distinct aspects of mitosis research. Part I presents approaches for visualizing and analyzing the dynamic behaviors of the spindle apparatus, the microtubule based machine that drives chromosome segregation. Part II focuses more generally on methods for studying and manipulating the microtubule cytoskeleton in cells and complex cell free extracts. Part III provides state of the art biophysical and high resolution microscopy approaches for assessing complex interactions between microtubules and microtubule-associated proteins in isolation as well as microtubule structure in cells. Part IV provides methods for studying the effects of cell shape on cell division and methods for quantifying aneuploidy (aberrant chromosome number) which frequently results from mitotic defects and has been linked to human maladies ranging from birth defects to cancer. Wr |
| 出版日期 | Book 2014 |
| 关键词 | cell division; chromosome segregation; complex cell free extracts; microtubule based machine; microtubul |
| 版次 | 1 |
| doi | https://doi.org/10.1007/978-1-4939-0329-0 |
| isbn_softcover | 978-1-4939-4301-2 |
| isbn_ebook | 978-1-4939-0329-0Series ISSN 1064-3745 Series E-ISSN 1940-6029 |
| issn_series | 1064-3745 |
| copyright | Springer Science+Business Media, New York 2014 |
发表于 2025-3-21 18:06:59
