| 书目名称 | Mitochondrial Mechanisms of Degeneration and Repair in Parkinson‘s Disease |
| 编辑 | Lori M. Buhlman |
| 视频video | |
| 概述 | Summarizes theories of how poor mitochondrial function and morphology contribute to neurodegeneration.Discusses both sporadic and familial forms of Parkinson‘s disease.Proposes potential molecules tha |
| 图书封面 |  |
| 描述 | This volume brings together various theories of how aberrations in mitochondrial function and morphology contribute to neurodegeneration in idiopathic and familial forms of Parkinson’s disease. Moreover, it comprehensively reviews the current search for therapies, and proposes how molecules are involved in specific functions as attractive therapeutic targets. It is expected to facilitate critical thought and discussion about the fundamental aspects of neurodegeneration in Parkinson’s disease and foster the development of therapeutic strategies among researchers and graduate students.Theories of idiopathic Parkinson’s etiology support roles for chronic inflammation and exposure to heavy metals or pesticides. Interestingly, as this project proposes, a case can be made that abnormalities in mitochondrial morphology and function are at the core of each of these theories. In fact, the most common approach to the generation of animal and cell-culture models of idiopathic Parkinson’s disease involves exposure to mitochondrial toxins. Even more compelling is the fact that most familial patients harbor genetic mutations that cause disruptions in normal mitochondrial morphology and function. |
| 出版日期 | Book 2016 |
| 关键词 | Drosophila melanogaster; Parkinson‘s Disease; dopaminergic neuron; mitochondria; neurodegeneration; react |
| 版次 | 1 |
| doi | https://doi.org/10.1007/978-3-319-42139-1 |
| isbn_softcover | 978-3-319-82507-6 |
| isbn_ebook | 978-3-319-42139-1 |
| copyright | Springer International Publishing Switzerland 2016 |
发表于 2025-3-21 17:46:27
