Titlebook: Microorganisms and Mental Health; Jonathan Savitz,Robert H. Yolken Book 2023 The Editor(s) (if applicable) and The Author(s), under exclus

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The Immune System and Depression: From Epidemiological to Clinical Evidence,gets, the immune system’s contribution to the pathogenesis of depression has received increased attention as immune activation has been associated with depression in various epidemiological and case-control studies. Epidemiological studies have shown that immune exposures such as severe infections a

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Infections, Inflammation, and Psychiatric Illness: Review of Postmortem Evidence,ave not yet detected an increased incidence of microbial nucleic acid or proteins in the brains of people with mental illness. Nevertheless, abnormally expressed immune and inflammatory markers have consistently been found in the postmortem brain of patients with schizophrenia and mood disorders. So

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Infections During Pregnancy and Risks for Adult Psychosis: Findings from the New England Family Stuatric disorders. The New England Family Study is a long-term prospective cohort study of over 16,000 individuals followed from the prenatal period for over 50 years. This chapter summarizes several major phases and findings from this work, highlighting recent results on maternal prenatal bacterial i

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Sources and Translational Relevance of Heterogeneity in Maternal Immune Activation Models,tivation (MIA) is still evolving, and so are the attempts to model this association in animals. Epidemiological studies of MIA offer the advantage of directly evaluating human populations but are often limited in their ability to uncover pathogenic mechanisms. Animal models, on the other hand, are l

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The Microbiome and Mental Health Across the Lifespan,ant of human health and disease. Although located predominantly on mucosal surfaces, these microorganisms have profound effects on brain functioning through the gut–brain axis.. The content of the chapter is based on a study group session at the annual meeting of the American College of Neuropsychop

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Fungal Forces in Mental Health: Microbial Meddlers or Function Fixers?, gene products and metabolites can access and influence the central nervous system (CNS). These GI-centered investigations focus on bacteria, with significant information gaps existing for other microbial community members, such as fungi. Fungi are part of a complex and functionally diverse taxonomi

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