Titlebook: Micromechanics of Contact and Interphase Layers; Stanisław Stupkiewicz Book 2007 Springer-Verlag Berlin Heidelberg 2007 Simulation.Transfo

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hypertension when a therapeutic plan that has included attention to lifestyle measures and prescription of at least three drugs (including a diuretic) at adequate doses has failed to lower systolic and diastolic BP. Many patients who present with resistant hypertension actually have pseudoresistant

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of blood pressure increase. Resistant hypertension is associated with a higher risk of cardiovascular complications, as a consequence of target organ damage, including cardiac abnormalities and vascular alterations in the macro- and microvasculature. The relationship between cardiovascular disease

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ded BP goals (i.e., below 140/90 mmHg) in the presence of lifestyle changes and optimal antihypertensive strategy based on at least three antihypertensive agents, including a diuretic at adequate doses. As such, this condition is associated with higher risk of cardiovascular morbidity and mortality

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of blood pressure increase. Resistant hypertension is associated with a higher risk of cardiovascular complications, as a consequence of target organ damage, including cardiac abnormalities and vascular alterations in the macro- and microvasculature. The relationship between cardiovascular disease

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ved. Today, several classes of effective antihypertensive drugs are available, and in particular ACE inhibitors, angiotensin II receptor blockers, calcium antagonists, diuretics and beta blockers are all considered first-line drugs by current European Guidelines; furthermore, other molecules may be

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pressure on optimal doses of three or more antihypertensive agents, ideally one being a diuretic. It causes cardiovascular and renal complications. RHTN may be a part of chronic kidney disease (CKD). RHTN diagnosis should be made early and treatment should be effective. Because it is a significant

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Homogeneous Surface Layers,lism is then applied to derive a phenomenological model of real contact evolution in metal forming processes. The predictions of the model are compared to other models and to available experimental data. Remarks are also provided regarding the application of the derived evolution law to modelling of