Titlebook: Microdialysis in Drug Development; Markus Müller Book 2013 American Association of Pharmaceutical Scientists 2013 Development.Drug.Microdi

AUGER

Translational Approaches for Predicting CNS Drug Effects Using Microdialysis barrier (BBB) and intracerebral distribution. It is, therefore, essential to have information on the unbound CNS target site pharmacokinetics, as this may distinctively differ from (unbound) plasma pharmacokinetics. Microdialysis studies on morphine, M3G, and M6G have shown the impact of different

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forebear

Microdialysis in Pain Researched new details on pain pathophysiology and the effect of interventions focused on pain relief such as drug treatment or training using microdialysiseither alone or in combination with other methods. This chapter focuses on the use of clinical microdialysis in pain research in healthy subjects and pa

薄膜

Calculus

Microdialysis in Metabolic Researchfluid by microdialysis in the brain of laboratory animals was a complement to ordinary blood sampling. Semipermeable hollow fibers were implemented in the brain-tissue mimicking characteristics of artificial blood vessels communicating with freely diffusing molecules in situ. Subcutaneous microdialy

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High Molecular Weight Targets and Treatments Using Microdialysiso obtain relevant biological samples, preferably from humans. Microdialysis sampling is a well-established and widely accepted method for the in vivo collection of solutes, including high molecular weight compounds, from a number of complex matrices, but principally from the extracellular fluid spac

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Complementary Techniques: Positron Emission Tomographys of drugs labeled with short-lived positron-emitting radionuclides, such as carbon-11 (.C, half-life: 20.4 min) or fluorine-18 (.F, half-life: 109.8 min). In addition, the availability of long-lived positron-emitters, such as bromine-76 (.Br, half-life: 16 h), iodine-124 (.I, half-life: 100.2 h), c