Titlebook: MicroRNAs: Key Regulators of Oncogenesis; Sadegh Babashah Book 2014 Springer International Publishing Switzerland 2014 Diagnosis.MicoRNA.O

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Nanocarriers and MicroRNA-Based Scenarios for Cancer Therapys. These nanotechnology-based delivery vehicles add a new armamentarium to the arsenal of miRNA- associated modalities of cancer treatment. Herein, we address in detail nanocarriers exploited for miRNA delivery. The nanocarriers based on eukaryotic viruses, lipids, polymers, bacteriophage MS2, gold

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Challenges and Strategies for Pulmonary Delivery of MicroRNA-Based Therapeuticsof tumor suppressive miRNA function and the inhibition of oncogenic miRNAs. In this chapter, we discuss the advantages of a pulmonary drug delivery system and the strategies for miRNA-based treatment of lung cancer.

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MicroRNAs and Cancer: An OverviewmRNAs for degradation and/or translational repression. MiRNAs have been widely investigated due to their potential role in regulating a variety of cellular processes, including proliferation, differentiation, and apoptosis. Many miRNAs are implicated in various human cancers. Functional analysis of

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Epigenetics, MicroRNAs and Human Cancer the cause of cancers. DNA methylation and histone modifications are the best-known epigenetic marks. MicroRNAs (miRNAs), a class of endogenous, single-stranded, non-coding small RNA with 18–22 nucleotides in length, play a critical role in initiation, progression, metastasis and invasion of cancers

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MicroRNAs, Diet and Cancer Chemoprevention cancer and contributes to differences in cancer incidence among various populations. Experimental evidence supports the role of dietary components as chemopreventive agents in various cancers. Dietary factors potentially influence fundamental cellular processes involved in carcinogenesis; including

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MicroRNAs in Solid Tumorsariety of biological processes in the cell, including development, cell differentiation, proliferation, apoptosis and their abnormal expression levels are closely associated with pathogenesis of cancers. In this scenario, several high-throughput technologies studies have revealed miRNA roles in clas

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MicroRNAs and Blood Cancersclear that dysfunctional expression of miRNAs is a characteristic of many, if not all, hematological malignancies. Many of the miRNAs aberrantly expressed in hematological malignancies also play a crucial regulatory role in normal hematopoietic function. In this chapter we review the evidence for th

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MicroRNAs and Oncogenic Human Virusesncode primary transcripts containing miRNA-like structures, and such transcripts are subjected to host miRNA processing pathway to generate viral miRNAs. Viral miRNAs derived from oncogenic viruses are often associated with tumor progression. Moreover, infections with oncogenic viruses alter the exp

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MicroRNAs Linking Cancer and Inflammation: Focus on Liver Cancerof specific miRNA signatures in various types of tumors, including hepatocellular carcinoma (HCC), highlighted the dual role of miRNAs, both oncogenic and tumor suppressive. HCC is a cancer of poor prognosis that mainly develops on an injured liver. Here, we will review the current knowledge concern