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Titlebook: Metastasis; Clinical and Experim K. Hellmann (Chairman),P. Hilgard (co-Chairman),S. Book 1980 Springer Science+Business Media Dordrecht 198

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A New In-Vitro Model to Study Tumour Cell Invasion,There is an urgent need to develop suitable models to study tumour cell invasion in tumour metastasis, however, there are only few available models (Leighton and Kline, 1954; Easty and Easty, 1963, 1974; Schleich et al., 1974; De Ridder et al., 1977; Kramer and Nicolson, 1979).
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Growth Inhibition of Simulated Metastases by a Large Primary Tumor,Cell cultures in diffusion chambers (DC) implanted into the abdominal cavity of host animals are a convenient method to study cell proliferation (Benestad 1970). Cell-to-cell interaction between cultured and host cells is prevented by the chamber walls, whereas the cultured cells may be freely exposed to humoral factors.
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The Spread of Rectal Cancer into Veins and the Mechanism of Distant Embolism,s (1930) states, distant metastases are generally the result of spread of tumour by the blood stream it is, perhaps, surprising that the relationship between local invasion of rectal veins and the development of blood borne distant metastases has not hitherto been well defined.
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Squamous Carcinomas of the Head and Neck: Patterns and Mechanisms of Local Invasion and Metastasis,ttern of growth and dissemination of this group of tumours is similar. The dominant features are local infiltration and metastasis to regional lymph nodes (Carter and Pittam, 1980). Clinically apparent metastases at distant sites are uncommon except in patients with carcinomas of the nasopharynx.
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The Relationship Between Malignant Melanoma Morphology, Metastases and Patient Survival,een paid to its dissemination to regional lymph nodes and to the management of clinically uninvolved nodes. However, it should be noted that melanomas often disseminate to distant organs without affecting regional lymph nodes.
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