Titlebook: Metallointercalators; Synthesis and Techni Janice Aldrich-Wright Book 2011 Springer-Verlag/Wien 2011 Biomolecular drug design.Inorganic Che

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Introduction to Nuclear Magnetic Resonance,range of applications in various fields of research [1,2]. Of all the analytical techniques in chemistry, NMR has been proven to be superior and extremely useful for the characterisation of complex mixtures, biomolecular structures and dynamics, molecular interactions and aggregations.

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,NMR Studies of Metallointercalator–DNA Interactions,ordén [3] and Barton [4] to the point that it is now a central theme in bio-inorganic chemistry. While there has been considerable interest in metal complexes that bind nucleic acids, the interaction of metallointercalators with DNA and RNA has received the most attention [5, 6]. Square-planar plati

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Mass Spectrometric Studies of Non-Covalent Binding Interactions Between Metallointercalators and DNpplications for molecules that can accomplish this task with high affinity and selectivity. As a result many workers have used a wide variety of experimental techniques, several of which are discussed in other chapters of this book, to unravel the details of the precise intermolecular interactions i

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Investigating Binding Interactions Using Linear Dichroism and Circular Dichroism,hether a putative metallointercalator does indeed bind to DNA intercalatively. In general, we require two pieces of evidence from completely different techniques that strongly suggest intercalation before we can conclude with any confidence that we do have a metallointercalator. The purpose of this

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Applications of Fluorescence Spectroscopy and Confocal Microscopy,racellular localisation of novel metallointercalators. Fluorescence is the property whereby some atoms or molecules absorb UV or visible light and then re-emit it at longer wavelengths after a brief interval, termed the fluorescence lifetime.

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Investigating the Biological Significance of Metallointercalators with cDNA Microarrays,c blueprint of all living things. All the information required for the development, operation and maintenance of cells is contained in a sequence of adenine (A), thymine (T), cytosine (C) and guanine (G) bases, where adenine is paired with thymine and cytosine is paired with guanine [1]. The DNA seq