Titlebook: Metal Compounds in Cancer Therapy; Simon P. Fricker Book 1994 Springer Science+Business Media Dordrecht 1994 cancer.cancer therapy.clinica

laceration

Rhodium, iridium and palladium compounds as experimental anticancer drugs,has concentrated on identifying platinum complexes having improved characteristics compared to cisplatin, there have also been numerous investigations involving other complexes of the transition metals. It is to be hoped that any new metal drug would have reduced toxic side-effects compared to plati

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,Organometallic titanium, vanadium, niobium, molybdenum and rhenium complexes — early transition met antitumour agents to show antitumour activity against numerous experimental animal and human carcinomas (Köpf and Köpf-Maier, 1979; Köpf-Maier Hesse and Köpf, 1980; Köpf-Maier, Leitner and Köpf, 1980; Köpf-Maier and Köpf, 1988) and entered phase I clinical studies in December 1991. It is one of the

molest

存心

Bleomycin and metal interactions,ibiotics possessing antitumour properties against several animal and human tumour lines. Early fractionation studies on the isolated bleomycin complex revealed at least 12 different components, with bleomycin A. accounting for 55-70% and bleomycin B. 25-32% of clinical preparations (Figure 9.1). The

积云

Palatial

Introduction,ctric field but by an electrolysis product formed by the interaction of dissolved platinum from the electrodes with ammonium in the culture medium (Rosenberg ., 1967). The product formed was identified as (NH.).[PtCl.]. This in turn was converted by a photochemical reaction to .-[PtCl.(NH3).].

Asperity

ACRID

努力赶上

The , use of metallic Radioisotopes in cancer detection and Imaging,-99m (.Tc) phosphates and phosphonates have proven to be useful for the detection of bone metastasis; and radioisotopes of rhenium (.Re, .Re), as the dimercaptosuccinic acid chelates, are under investigation for therapy of certain tumours. Recently, methods for the attachment of .Tc, the radioiodine

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