| 书目名称 | Membrane Proteins in Aqueous Solutions | | 副标题 | From Detergents to A | | 编辑 | Jean-Luc Popot | | 视频video | | | 概述 | First book dedicated to the art of handling membrane proteins in aqueous solutions.Includes a Foreword by Donald M. Engelman and over 30 cartoons created by Francis Haraux.Includes over 400 richly ill | | 丛书名称 | Biological and Medical Physics, Biomedical Engineering | | 图书封面 |  | | 描述 | .This book is the first to be entirely devoted to the challenging art of handling membrane proteins out of their natural environment, a key process in biological and pharmaceutical research, but one plagued with difficulties and pitfalls. Written by one of the foremost experts in the field, .Membrane Proteins in Aqueous Solutions .is accessible to any member of a membrane biology laboratory. After presenting the structure, functions, dynamics, synthesis, natural environment and lipid interactions of membrane proteins, the author discusses the principles of extracting them with detergents, the mechanisms of detergent-induced destabilization, countermeasures, and recent progress in developing detergents with weaker denaturing properties. Non-conventional alternatives to detergents, including bicelles, nanodiscs, amphipathic peptides, fluorinated surfactants and amphipols, are described, and their relative advantages and drawbacks are compared. The synthesis and solution properties of the various types of amphipols are presented, as well as the formation and properties of membrane protein/amphipol complexes and the transfer of amphipol-trapped proteins to detergents, nanodiscs, lipidi | | 出版日期 | Book 2018 | | 关键词 | Amphipols Reviewed; Membrane Protein Folding; Membrane Protein Stability; Membrane Protein Structural S | | 版次 | 1 | | doi | https://doi.org/10.1007/978-3-319-73148-3 | | isbn_softcover | 978-3-030-10324-8 | | isbn_ebook | 978-3-319-73148-3Series ISSN 1618-7210 Series E-ISSN 2197-5647 | | issn_series | 1618-7210 | | copyright | Springer International Publishing AG, part of Springer Nature 2018 |
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发表于 2025-3-21 18:32:42
