Titlebook: Membrane Protein Structure; Experimental Approac Stephen H. White (Professor of Physiology and Biop Book 1994 American Physiological Societ

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Hydropathy Plots and the Prediction of Membrane Protein Topology1978; Rose and Roy, 1980; Kyte and Doolittle, 1982) and membrane (Argos et al., 1982; Kyte and Doolittle, 1982; Engelman et al., 1986) proteins. They have been especially important for membrane proteins, however, because the determination of three-dimensional structures is more problematic. The data

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Use of Gene Fusions to Determine Membrane Protein Topologyded within it. The topological model can be considered a set of constraints on the possible three-dimensional structures for the protein. As such, a simple topological model contains a great deal of information about the structure of the protein, since it greatly limits the number of possible three-

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Structure of F0F1ATPases Determined by Direct and Indirect Methodsmical pathway. The reaction involves the utilization of the proton electrochemical gradient, produced by either the oxidation of substrates or the utilization of light quanta, for the generation of ATP levels up to 10. times the concentration expected from the hydrolytic equilibrium (ATP + H.O = ADP

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Experimental Determination of Membrane Protein Secondary Structure Using Vibrational and CD Spectrosue: the measurements must be reliable and specific enough to help distinguish between competing models of structure or function. An example of how this issue plays itself out can be seen in a series of papers beginning with that of Jap et al. (1983), in which it was proposed that some of the images

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High-Resolution Electron Crystallography of Membrane Proteinsrecently, x-ray crystallography seemed to be the only promising method. Progress with this technique, however, has not been as rapid as originally hoped because it is difficult to grow large and sufficiently well-ordered three-dimensional crystals. Electron crystallography of two-dimensional crystal

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