Titlebook: Membrane Microdomain Signaling; Lipid Rafts in Biolo Mark P. Mattson Book 2005 Humana Press 2005 aging.apoptosis.biology.cancer.membrane.me

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Regulatory Aspects of Membrane Microdomain (Raft) Dynamics in Live Cells,ins are enriched in glycosphingolipids and cholesterol and are resistant to solubilization with nonionic detergents; they are therefore called detergent-insoluble-glycolipid enriched membrane (DIG) or glycosphingolipid enriched membrane (GEM). These domains, also called “lipid rafts” (Simons and Iko

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Role of Cholesterol in Membrane Microdomain Signaling,ins has been shown (Dietrich et al., 2001, 2002). Over the last decade, evidence has accumulated that comparable structures are present in the plasma membranes of living cells (Anderson, 1998; Smart, et al, 1999; Simons and Toomre, 2000; Fielding and Fielding, 2000; Parton, 2003). Because of their l

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Raft Lipid Metabolism in Relation to Alkyl-Lysophospholipid-Induced Apoptosis,ompared to the bulk of the plasma membrane. Membrane fluidity is inversely related to the degree of packing of the various apolar acyl and sphingoid chains of phospho- and (glyco)sphingolipids with cholesterol (van Blitterswijk et al., 1987). Lipid rafts have low fluidity (high rigidity) and can onl

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