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Titlebook: Melanoma Techniques and Protocols; Molecular Diagnosis, Brian J. Nickoloff,Leroy Hood (President and Direc Book 2001 Humana Press 2001

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发表于 2025-3-21 16:53:57 | 显示全部楼层 |阅读模式
书目名称Melanoma Techniques and Protocols
副标题Molecular Diagnosis,
编辑Brian J. Nickoloff,Leroy Hood (President and Direc
视频video
概述Includes supplementary material:
丛书名称Methods in Molecular Medicine
图书封面Titlebook: Melanoma Techniques and Protocols; Molecular Diagnosis, Brian J. Nickoloff,Leroy Hood (President and Direc Book 2001 Humana Press 2001
描述This book is about melanoma—its biology, immunology, and pathology, as well as the initial use of powerful genomic tools to study its fundamental mole- lar and genetic characteristics. The study of cancer will be profoundly impacted by the Human Genome Project. I would like to discuss some of these changes. The first draft of the human genome sequence was announced in June 2000, and we have just scratched the surface of the changes it will engender in medicine. A relevant question is what are the long-term effects of the Human Genome Project for medicine? I would argue that there are three, and each of these three point toward the view that systems biology will dominate biology and medicine of the 21st century. First, the Human Genome Project introduced a new type of s- ence—discovery science. Discovery science takes a biological system (e. g. , the genome) and defines all of its elements (e. g. , the sequences of the 24 human ch- mosomes). Thus, it creates a rich infrastructure from which the classical hypo- esis-driven science can be done more effectively. The effective integration of discovery- and hypothesis-driven science is a key for systems approaches to bi- ogy and medicine
出版日期Book 2001
版次1
doihttps://doi.org/10.1385/1592591450
isbn_softcover978-1-61737-134-9
isbn_ebook978-1-59259-145-9Series ISSN 1543-1894 Series E-ISSN 1940-6037
issn_series 1543-1894
copyrightHumana Press 2001
The information of publication is updating

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Marten Visser,Markwin P. Velders,Michael P. Rudolf,W. Martin Kast
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Genetic Testing in Familial Melanoma, about 8–12% of melanoma is inherited as an autosomal dominant trait with variable penetrance. Affected members (AFM) of these FMM kindreds may develop multiple primary melanoma (.) and/or pancreatic cancer (.) and typically present at an earlier age than do patients with sporadic disease. In a sub
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Role of Molecular Biology in Diagnostic Pathology of Melanomaed dysplastic melanocytic nevus, melanocytic dysplasia on the acral or mucosal surface, spindle cell and/or atypical epithelioid melanocytic nevus (Spitz nevus), and dysplastic and/or congenital nevus spilus (.–.).
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Identification of Altered Gene Expression Associated with Pigmentary Lesions by Differential Displayseparated by polyacrylamide gel electrophoresis. Using a labeled nucleotide in the PCR reaction, the intensity of each band can subsequently be compared in samples of interest. Following reamplification, confirmation, cloning, and sequencing, the fragments of interest are further analyzed. . outline
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Fluorescence , Hybridization as a Tool in Molecular Diagnostics of Melanomad unbalanced translocations, inversions and deletions) (., e.g., German Collection of Microorganisms and Cell Cultures [Dr. H. Drexler] at . (.,.). Cytogenetic analysis of malignant melanoma cells allowed the identification of nonrandom karyotypic changes involving chromosomes 1, 6, and 7 and, to so
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Gene Therapy in Melanoma, therefore, the appropriate vector should be selected according to the therapeutic system involved (.). Retro viral vectors have been used largely for their ability to selectively transfect proliferating cells, a feature that can be advantageous in case one wishes to target only proliferating tumor
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