Titlebook: Melanoma Antigens and Antibodies; Ralph A. Reisfeld,Soldano Ferrone Book 1982 Plenum Press, New York 1982 antibody.antigen.cancer.cancer r

Fester

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Immunotherapy of Melanoma,nse to those TATAs? Does clinical malignancy develop because of a failure of the normal immunological response to the tumor? The answers to these very basic questions of tumor immunology are unknown at present, and it seems unlikely that they will be answered in the near future.

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PHIL

Monoclonal Antibodies as a Tool to Detect Melanoma-Associated Antigens,ler and Seigler, 1975; Viza and Phillips, 1975). The major drawback of such antisera is, however, the overwhelming number of contaminating antibodies that have to be removed by extensive absorption before any tumor specificity can be demonstrated.

LURE

Book 1982ral, and biological char­ acterization of human melanoma constitutes one area of research that has received consid­ erable attention from researchers and clinicians and has generated new and exciting infor­ mation. In this volume, we have attempted to assemble work on topics that produced some of th

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Shedding and Degradation of Cell-Surface Macromolecules and Melanoma-Associated Antigens by Human Md cellular immune destruction of malignant cells and thus may enhance tumor growth. Since these effects can be mediated by soluble tumor antigens, the factors that influence their accumulation in body fluids may have an important impact on tumor growth.

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Heterogeneity of Human Melanoma-Associated Antigens Revealed by Alloantisera and Xenoantisera,ecific antigens that function as rejection antigens exist? (2) Are these antigens immunogenic in man, and if they are, how should they be measured? (3) Are there antigens on melanoma cells that are recognized only by heterologous species, and if there are, might they be of any use in immunodiagnosis and therapy?

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Protein Antigens of Mouse Melanomas,ensitized hosts, exhibit . behavior different from that observed following administration into naïve hosts (Fidler ..,1977; Gersten, 1980). It follows, then that B16 cells should possess unique molecules that are both absent from other C57BL/6 cells and immunogenic.

LURE

l, structural, and biological char­ acterization of human melanoma constitutes one area of research that has received consid­ erable attention from researchers and clinicians and has generated new and exciting infor­ mation. In this volume, we have attempted to assemble work on topics that produced

Yag-Capsulotomy

The Nature and Significance of Melanoma Antigens Recognized by Human Subjects,f more stringent criteria of tumor specificity and different assay techniques, there has been renewed debate on the specificity of many of these antigens for melanoma and whether they are the focus of tumor-related immune responses by patients with melanoma.