Titlebook: Mechanosensitive Ion Channels; Andre Kamkin,Irina Kiseleva Book 2008 Springer Science+Business Media B.V. 2008 Activation.Cell mechanobiol

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Role of Lipid Bilayer Mechanics in Mechanosensationmechanosensation is rapidly advancing as a result of both structural and functional studies. One intriguing mode of mechanosensation results from tension in the membrane of the cell (or vesicle) of interest. The aim of this review is to catalogue recent work that uses a mix of continuum and statisti

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Mechanosensitive Channels Gated by Membrane Tensionnderlying channels that are gated by mechanical forces. Two quite different models now exist. The first is that the channels are ‘tethered’ to cytoskeleton and or extracellular components, which thus exert forces on the channel that lead to gating. The second model predicts that the channel protein

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Mechanosensitive Ion Channels in Odontoblastssmission. They are organized as a single layer of specialized cells along the interface between dental pulp and calcified dentinal tubules into which run a cellular extension (odontoblast process) bathed in a liquid phase. Dense sensory unmyelinated nerve fibres surrounded the odontoblast bodies, co

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Mechanosensitive Channel TRPV4poosmolality-activated Ca. permeable channel. The mechanism of opening by hypoosmolality is distinct from direct coupling of membrane tension with conformational changes, such as that which occurs with Msc or TREK, in which phospholipase A2 is sensitive to hypoosmolality and the resulting arachidoni

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Mechanosensitive Purinergic Calcium Signalling in Articular Chondrocytesel, bone, ligament and cartilage, mechanotransduction is essential for tissue health and function. Although mechanotransduction mechanisms have been identified in a number of tissues, the signalling pathways have not yet been elucidated in articular cartilage. This chapter explores the influence of