Titlebook: Mechanisms of Transcription; Fritz Eckstein,David M. J. Lilley Book 1997 Springer-Verlag Berlin Heidelberg 1997 DNA.Escherichia coli.Promo

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Book 1997quences, and the structures of the various components on the transcriptional machinery. Both prokaryotic and eukaryotic systems, NMR and crystallographic structures of a number of important eukaryotic transcription factors are discussed, as well as the role of chromatin structure.

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Promoter Selectivity Control of RNA Polymerase,scription initiation from promoters. Each σ subunit recognizes a different set of promoters and therefore the promoter selectivity of RPase can be modulated by replacement of the σ subunit (Helmann and Chamberlin 1988; Ishihama 1988). At present, seven different molecular species of σ subunit are known to exist in ..

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Translocation of DNA-Dependent , RNA Polymerase During RNA Synthesis,olymerase stops momentarily at certain sequences, termed “pause” sites, before resuming RNA synthesis. However, only in a few cases has it been possible to establish a correlation between pausing sites and the primary or the secondary structure surrounding the pause sites (Aivazashvili et al. 1981; Theissen et al. 1990; Fedoseyeva et al. 1994)

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Understanding SRY-Related 46X,Y Sex Reversal at the Atomic Level,er through mutations in SRY or because of chromosomal makeup (viz. XX females), the primordial gonad develops into ovaries. One potential target for SRY is the promoter for the gene encoding the Müllerian inhibtory substance (MIS) whose product is responsible for the regression of the female Müllerian ducts.

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0933-1891 stallographic structures of a number of important eukaryotic transcription factors are discussed, as well as the role of chromatin structure.978-3-642-64509-9978-3-642-60691-5Series ISSN 0933-1891 Series E-ISSN 1869-2486

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Fundamental Aspects of T7 RNA Polymerase Structure and Mechanism,make rapid progress in the study of these large and fragile macromolecules and the complex reactions they carry out. While necessary and productive, these more qualitative studies necessarily left our understanding of some aspects of polymerase mechanism rather sketchy.

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Ribosomal RNA Promoter-RNA Polymerase Interactions and rRNA Transcription in ,, rates, the promoters for the seven . rRNA operons transcribe well over half the cell’s total RNA (Bremer and Dennis 1987). The special mechanisms that make rRNA promoters so active will be a major focus of this chapter.