Titlebook: Mechanisms of Receptor Regulation; George Poste,Stanley T. Crooke Book 1985 Plenum Press, New York 1985 Antigen.cancer.catecholamines.drug

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Patterns in Receptor Behavior and Function,ules that govern that set’s behavior. For example, the properties of molecules are defined by physicochemical principles that limit their behavior. By defining the “rules” that dictate a molecule’s behavior, predictions can be made regarding the behavior of other members in a similar set; i.e., patt

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The Insulin Receptor as a Tyrosine- Specific Protein Kinase,ts receptor generates a biological signal (Cobb and Rosen, 1984). Evidence for mediation of insulin action by a small peptide second messenger has been presented (Larner .., 1978; Seals and Jarrett, 1980; Seals and Czech, 1980). Recently, however, the discovery that the insulin receptor is associate

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CREST

Receptor-Controlled Phosphatidylinositol 4,5-Bisphosphate Hydrolysis in the Control of Rapid Receptogical and pharmacological work was largely ignored by most biochemists until quite recently (e.g., Rasmussen, 1969; Berridge, 1975). Moreover, the discovery of cAMP in the 1950s established a pattern of thought, particularly dominant among biochemists in the 1960s, in which the search for cellular

OATH

Inositol Trisphosphate and Diacylglycerol as Intracellular Second Messengers,of these agonists is to stimulate the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP.) to produce diacylglycerol (DG), which remains in the plane of the membrane, and inositol 1,4,5-trisphosphate (IP.), which is released to the cytoplasm (for details see Michell, Chapter 6). The fascinatin

古董

Ionic Signal Transduction by Growth Factors,tor proteins in the plasma membrane receive and transduce growth-stimulatory signals that trigger a cascade of biochemical and physiological changes in the cell. Ultimately, this chain of events culminates in replicative DNA synthesis and cell division. Among the most extensively studied mitogens ar

Cardiac-Output

Guanine-Nucleotide-Binding Regulatory Proteins,ly of guanine-nucleotide-binding regulatory proteins. This family is now known to include at least four highly homologous members. We can, at this time, formulate general definitions and hypotheses about the family and its functions.

Asperity

Role of Cyclic-AMP-Dependent Protein Kinase in the Regulation of Cellular Processes,ct cAMP-dependent protein kinase, which exhibited broader specificity than that of a phosphorylase kinase kinase in that it could also catalyze the phosphorylation of casein and protamine (Walsh .., 1968). Huijing and Larner (1966) had also concluded that the target for cAMP-mediated regulation of g