Titlebook: Mechanisms of Molecular Carcinogenesis – Volume 1; Johannes Haybaeck Book 2017 Springer International Publishing AG 2017 cancer biomarkers

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Translational Control and mTOR in Cancer,tumor entities that might be sensitive to mTOR targeting, we chose glioblastoma (GBM) and colorectal cancer to report the current state of investigation. In these exemplary tumor types, we review the potential of mTOR pathway components as biomarkers as well as drug targets.

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Carcinogenesis in the Epithelium of the Upper Aerodigestive Tract,cer have a significantly better prognosis than patients without HPV infection, regardless of the type of treatment. Currently, it still needs to be clarified whether the HPV vaccination program for cervical cancer will have a future impact on the incidence of oropharyngeal cancer.

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Carcinogenesis of Sinonasal Carcinomas,re exposed to wood dust. Research on signaling pathways and genetic studies are still ongoing, and the first promising results may lead to future development of targeted tumor therapy, where today surgery combined with radio-(chemo)therapy is still the primary choice of treatment (Nat Rev Clin Oncol 11(8):460–472, 2014).

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ght into signaling pathways and tumor metabolism. Divided into two volumes the work offers a so far unmatched broad and at the same time deep knowledge on molecular and cellular mechanisms of carcinogenesis and offers comprehensive insight into clinical, therapeutic and technological aspects. This 1

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Molecular Aspects of Thyroid Carcinogenesis,er entity is more frequent in women than in men, with incidence ratios of approximately 3:1. This chapter will introduce the main features of thyroid cancer development, especially focusing on altered molecular signaling and epigenetic variations.

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,NF-κB and Its Implication in Liver Health and Cancer Development,metabolic and inflammatory processes: the liver. It seems that NF-κB is pivotal for the homeostasis in the different hepatic cell types concerning hepatic failure, fibrosis, and HCC progression. NF-κB has the ability to be a potential target in the attempt to circumvent or medicate liver fibrosis and HCC.

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Molecular Carcinogenesis of Glial Brain Tumors,enetic changes, i.e., altered methylation patterns. Studies related to gene or microRNA (miR) expression in brain tumors are still scarce. Brain tumors pose a challenging task for the clinician and require further broad-minded molecular investigations at various levels.

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