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Titlebook: Mechanisms of Lymphocyte Activation and Immune Regulation III; Developmental Biolog Sudhir Gupta,William E. Paul,Ellen V. Rothenberg Book 1

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书目名称Mechanisms of Lymphocyte Activation and Immune Regulation III
副标题Developmental Biolog
编辑Sudhir Gupta,William E. Paul,Ellen V. Rothenberg
视频video
丛书名称Advances in Experimental Medicine and Biology
图书封面Titlebook: Mechanisms of Lymphocyte Activation and Immune Regulation III; Developmental Biolog Sudhir Gupta,William E. Paul,Ellen V. Rothenberg Book 1
描述Recent advances in the understanding of the major events that shape the immune recog­ nition system have been remarkable. The analysis of immunoglobulin (Ig) gene organization and Ig repertoire diversification in lower vertebrates has provided new insight into this process in mammals. Similarly, the understanding of the early development of lymphocytes and of the acquisition of immunological tolerance has been aided by elegant studies in quail/chicken chimeras, using the power of the distinctive markers of the constitutive cells of these birds. Great strides have been made in understanding the role played by major histocompatibility complex (MHC) molecules in antigen presentation and in repertoire selec­ tion within the thymus. The use of transgenic mice expressing specific T-cell receptor (TCR) genes has elucidated the process of both positive and negative selection. In parallel, there has been considerable progress in our understanding of tolerance, based in part on the use of markers for the V fJ genes of T-cell receptors and in part on the analysis of the behavior of long term T-cell lines. This has led to the realization that both clonal deletion and clonal anergy may play cri
出版日期Book 1991
关键词Antigen; antigen presentation; cells; development; histocompatibility; immunoglobulin; lymphocytes; system;
版次1
doihttps://doi.org/10.1007/978-1-4684-5943-2
isbn_softcover978-1-4684-5945-6
isbn_ebook978-1-4684-5943-2Series ISSN 0065-2598 Series E-ISSN 2214-8019
issn_series 0065-2598
copyrightThe Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Busines
The information of publication is updating

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Kinetics of Negative and Positive Selection in the Thymusfic peptide. Different tolerogens delete CD4.8. thymocytes earlier or later during their lifespan and negative selection can occur prior to positive selection. The specificity of the . T cell receptor for either class I or class II thymic MHC molecules determines the CD4.8. and CD4.8. phenotype of mature T cells.
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First Wave Fetal Thymocytes Expressing V3Jγ1Cγ1-Vδ1Jδ2Cδ T Cell Receptors are not Required For , T Cr the rearrangement, expression and maturation of the . TcR repertoire. We are currently analyzing a series of γ. transgenic mice to determine whether other restricted populations of γ.-bearing T cells are involved in specific aspects of immune development or function.
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T Cells in Murine Epithelia: Origin, Repertoire, and Functionmprise the bulk, if not the entirety, of the T cells. There is a tight correlation between Vγ gene usage and epithelial localization as well as differences in the potential TCR repertoire in the different epithelia, two features which raise important questions as to the origin, homing, selection, and function of these cells.
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Monoclonal Antibodies Against T Cell Receptor/CD3 Complex Induce Cell Death of Th1 Clones in the Abses signals. Numerous studies indicate that such recognition can result in a variety of consequences, including cell proliferation, cytokine production, cell death,. and clonal anergy.. However, the mechanisms by which the outcomes of T cell recognition is determined are largely unknown.
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Multiple Mechanisms of T Cell Tolerance to Mls-latolerance. Three mechanisms have been proposed for maintaining self tolerance-clonal deletion, or elimination of self-reactive clones, clonal anergy, or functional inactivation of self-reactive clones, and suppression, or negative regulation of self-reactive clones.
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0065-2598 and in part on the analysis of the behavior of long term T-cell lines. This has led to the realization that both clonal deletion and clonal anergy may play cri978-1-4684-5945-6978-1-4684-5943-2Series ISSN 0065-2598 Series E-ISSN 2214-8019
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