书目名称 | Mechanisms of Lymphocyte Activation and Immune Regulation III |
副标题 | Developmental Biolog |
编辑 | Sudhir Gupta,William E. Paul,Ellen V. Rothenberg |
视频video | |
丛书名称 | Advances in Experimental Medicine and Biology |
图书封面 |  |
描述 | Recent advances in the understanding of the major events that shape the immune recog nition system have been remarkable. The analysis of immunoglobulin (Ig) gene organization and Ig repertoire diversification in lower vertebrates has provided new insight into this process in mammals. Similarly, the understanding of the early development of lymphocytes and of the acquisition of immunological tolerance has been aided by elegant studies in quail/chicken chimeras, using the power of the distinctive markers of the constitutive cells of these birds. Great strides have been made in understanding the role played by major histocompatibility complex (MHC) molecules in antigen presentation and in repertoire selec tion within the thymus. The use of transgenic mice expressing specific T-cell receptor (TCR) genes has elucidated the process of both positive and negative selection. In parallel, there has been considerable progress in our understanding of tolerance, based in part on the use of markers for the V fJ genes of T-cell receptors and in part on the analysis of the behavior of long term T-cell lines. This has led to the realization that both clonal deletion and clonal anergy may play cri |
出版日期 | Book 1991 |
关键词 | Antigen; antigen presentation; cells; development; histocompatibility; immunoglobulin; lymphocytes; system; |
版次 | 1 |
doi | https://doi.org/10.1007/978-1-4684-5943-2 |
isbn_softcover | 978-1-4684-5945-6 |
isbn_ebook | 978-1-4684-5943-2Series ISSN 0065-2598 Series E-ISSN 2214-8019 |
issn_series | 0065-2598 |
copyright | The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Busines |