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Titlebook: Mechanisms of Insulin Action; Alan R. Saltiel,Jeffrey E. Pessin Book 2007 Springer-Verlag New York 2007 Actions.Diabetes.Diabetes mellitus

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书目名称Mechanisms of Insulin Action
编辑Alan R. Saltiel,Jeffrey E. Pessin
视频video
概述Attempts to dissect the complexity of the molecular mechanisms of insulin action with a special emphasis on those features of the system that are subject to alteration in type 2 diabetes and other ins
丛书名称Medical Intelligence Unit
图书封面Titlebook: Mechanisms of Insulin Action;  Alan R. Saltiel,Jeffrey E. Pessin Book 2007 Springer-Verlag New York 2007 Actions.Diabetes.Diabetes mellitus
描述.More than 18 million people in the United States have diabetes mellitus, and about 90% of these have the type 2 form of the disease. In addition, between 17 and 40 million people have insulin resistance, impaired glucose tolerance, or the cluster of abnormalities referred to variably as the metabolic syndrome, the dysmetabolic syndrome, syndrome X, or the insulin resistance syndrome. In all of these disorders, a central component of the pathophysiology is insulin resistance, i.e., reduced responsiveness to insulin in tissues such as muscle, fat and liver. Insulin resistance is also closely linked to other common health problems, including obesity, polycystic ovarian disease, hyperlipidemia, hypertension, and atherosclerosis. In this book, we will attempt to dissect the complexity of the molecular mechanisms of insulin action with a special emphasis on those features of the system that are subject to alteration in type 2 diabetes and other insulin resistant states. We explore insulin action at the most basic levels, through complex systems. The book will be appealing to basic and clinical scientists..
出版日期Book 2007
关键词Actions; Diabetes; Diabetes mellitus; Insulin; Insulin Secretion; Mechanisms; genes; hypertension; molecular
版次1
doihttps://doi.org/10.1007/978-0-387-72204-7
isbn_softcover978-1-4419-2469-8
isbn_ebook978-0-387-72204-7
copyrightSpringer-Verlag New York 2007
The information of publication is updating

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Regulation of Insulin Action and Insulin Secretion by SNARE-Mediated Vesicle Exocytosis,sulin secretion and glucose uptake are regulated exocytotic processes mediated by SNARE protein complexes. SNARE core complexes are heterotrimeric, composed of syntaxin, SNAP-25/23 and VAMP2 proteins in a 1∶1∶1 ratio. It has become clear that we must thoroughly define the precise mechanisms underlyi
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,Insulin Action in the Islet β-Cell,evaluate the roles of the insulin and IGF-1 receptors and proteins in their signaling pathway in islet cells. While a functional role for insulin signaling in islet β-cells is now well established, the precise pathways and proteins that mediate β-cell growth and function during development and adult
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Central Regulation of Insulin Sensitivity, insulin modulates hepatic glucose production involve either activation of insulin signaling in hepatocytes (direct efects) or activation of insulin receptors in extra-hepatic sites (indirect effects), which in turn leads to inhibition of glucose production via neural and/or humoral mediators. The d
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Transgenic Models of Impaired Insulin Signaling,es. The predisposition to insulin resistance results from genetic and environmental factors. The search for gene variants that predispose to insulin resistance has been thwarted by its genetically heterogeneous pathogenesis. However, using techniques of targeted mutagenesis and transgenesis in roden
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