Titlebook: Mechanisms of Gene Regulation: How Science Works; Carsten Carlberg,Ferdinand Molnár Textbook 2020 Springer Nature Switzerland AG 2020 Tran

不可磨灭

Basal Transcriptional Machinery,core of the basal transcriptional machinery that contains a large number of general transcription factors, such as the TATA box binding protein (TBP), many of which are summarized as the TFIID complex. The TATA box is the prototype of a site-specific transcription factor binding site determining the

多产鱼

disrupt

A Key Transcription Factor Family: Nuclear Receptors,unctional and structural aspects of transcription factors, such as the interaction with co-activator and co-repressor proteins. Many of the 48 human members of the largest family of transcription factors in metazoans have the unique property to be specifically activated by small lipophilic ligands i

ZEST

Genome-Wide Principles of Gene Regulation,ription factor binding sites that are under evolutionary control. However, only in combination with experimental data obtained by Big Biology projects like . such . approaches are effective. The rapidly increasing amount of ChIP-seq data on transcription factor locations and multiple histone modific

STERN

Chromatin Modifiers,, gene expression and development. Histone modifying enzymes, such as HATs, HDACs, KMT and lysine demethylases (KDMs), either add or remove post-translational modifications, such as acetylations and methylations, to histone proteins and in this way change the functional profile of the epigenome. The

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Epigenetics,nd 3D organization of the DNA. During development patterns of gene repression are established by both DNA methylation and histone modification. Histone methylation causes easily reversible local formation of heterochromatin, whereas DNA methylation mostly leads to stable long-term repression. Aberra

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沙发

Regulatory Impact of Non-coding RNA,s giving rise to tens of thousands of ncRNAs. Not all of these transcripts are functional, however, many ncRNAs have regulatory specificity, ., some of them function similarly to proteins. miRNAs are small ncRNAs that regulate post-transcriptionally the expression of several thousand genes. They sha

Gesture

Calibrate