Titlebook: Mechanisms of Gene Regulation; Carsten Carlberg,Ferdinand Molnár Textbook 2016Latest edition Springer Science+Business Media Dordrecht 201

Small-Intestine

The Basal Transcriptional MachineryII is controlled. Pol II is the core of the basal transcriptional machinery that contains a large number of basal transcription factors, many of which are summarized as the TFIID complex. Via another multi-protein complex of co-activators, termed the Mediator complex, the basal transcriptional machi

不怕任性

Robust

Linking Signal Transduction and Gene Regulationascades that mostly start with an extra-cellular signaling molecule and end with an activated transcription factor. Latent transcription factors, such as SMADs, STATs, NF-κB and others, are central to these pathways, as they are activated through different mechanisms of their translocation from the

强所

Switching Genes On and Off: The Example of Nuclear Receptorsin the size of cholesterol (approximately 400 Da). Some of these ligands are known as endocrine hormones, such as estradiol and testosterone, while others are metabolites of dietary compounds, such as fatty acids and cholesterol. Both types of molecules are of large physiological impact in health an

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捐助

Chromatin Modifiershanges control many biological processes, such as cellular differentiation in the context of embryogenesis. The present understanding of the function of histone modifications is summarized in the histone code model..There are two pairs of chromatin modifying enzymes, each with antagonizing activity,

憎恶

Genomic Imprinting. Insulators are genomic loci that separate genes located in one chromatin region from promiscuous regulation by transcription factors binding to enhancers of neighboring chromatin regions. The genome regulator CTCF has tens of thousands DNA binding sites in human cells, many of which are located in

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CANON

Chromatin Architectureomatin domains are located in the nuclear interior, whereas silent domains reside at the nuclear periphery. Global changes in gene expression correlate with spatial chromatin reorganizations that play a significant role during development. Thus, transcriptionally active genes are involved in the pro