Titlebook: Mechanisms of Cancer Metastasis; Potential Therapeuti Kenneth V. Honn,William E. Powers,Bonnie F. Sloane Book 1986 Martinus Nijhoff Publish

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Kenneth V. Honn,William E. Powers,Bonnie F. Sloane

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Cancer Cell Procoagulants and their Possible Role in Metastasis,brin strands attached to them. In addition, several investigators have demonstrated that anticoagulant therapy of animals with heparin (2,12,13), warfarin (2,12,14–18), proteinase inhibitors (19) and defibrination (20,21) as well as fibrinolytic therapy (2,22–24) decreases metastasis. On the other h

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Biological Response Modifiers as Activators of Natural Killer Cells: Potential Role in Treatment ofwith a morphologic cell type, the large granular lymphocyte (LGL). Over the last several years there has been a rapid increase in our knowledge of the characteristics of NK cells, attributable largely to the ability to highly purify this cell population, either by Percoll density gradient centrifuga

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Chemotaxis in Tumor Cells: Possible Mechanisms and their Implications for Therapy,d factor with tumor cell chemotactic activity is biochemically and immunochemically similar to the C5 (i.e., C5a) leukocyte chemotactic factor (5–7). This suggested that there might be similarities between leukocytes and tumor cells in their responses to chemotactic factors. We postulated that tumor

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Domains of Laminin and Basement Membrane Collagen which Play a Role in Metastases,ibrosarcoma cells (4). Murine melanoma cells can be selected for metastatic propensity based on their ability to use laminin to attach to type IV collagen .. (10). Those tumor cells which preferentially utilize laminin for attachment exhibit a ten fold increase in metastatic propensity (10). By elec

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Book 1986jor objectives of this book were to present the most recent advances in our understanding of how tumor cells metastasize to secondary sites by the leading experts in the biology of tumor invasion and metastasis. We hope that this book will lead to new concepts for the treatment of subclinical metast

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gy. The major objectives of this book were to present the most recent advances in our understanding of how tumor cells metastasize to secondary sites by the leading experts in the biology of tumor invasion and metastasis. We hope that this book will lead to new concepts for the treatment of subclinical metast978-1-4612-9646-1978-1-4613-2635-9

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tion problem. The validity of the algorithm is verified using two cases of three-bar truss design optimization problem. CIFL is applied to both discrete and continuous variable-constrained problems. The self-adaptive penalty function (SAPF) approach is used to handle the constraints. The results obt