Titlebook: Mechanisms in B-Cell Neoplasia 1992; Workshop at the Nati Michael Potter (Chief),Fritz Melchers (Director) Book 1992 The Editor(s) (if appl

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In Vitro Growth and Maturation of Human B-Cell Precursorsokines, in the presence or absence of a fibroblastic stromal cell layer derived from adult human BM. We demonstrated that IL-7, IL-3, and stem-cell factor (SCF) participate in inducing low magnitude BCP proliferation in the absence of stroma. Addition of either IL-4, IFN (α and γ), or TGFß, resulted

stress-response

Modulation of Signal Transduction in Phosphocholine-Specific B Cells from μκ Transgenic Micerned over since 2/3 of the peripheral B cell pool is comprised of longlived μ+δ+ B cells (2). Recent studies indicate that newly generated B cells are selected into this long-lived pool via an Ig V region-mediated process that appears to involve internal autoantigens or external environmental antige

inclusive

Activities Involved in V(D)J Recombinationous components. In a simplified view, the recombination mechanism involves recognition of conserved heptamer-spacer-nonamer recombination sequences (RS) that flank each germline V, D, or J segment, Introduction of double stranded breaks between the elements to be joined and the flanking RS elements,

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Double-Strand Breaks Associated with V(D)J Recombination at the TCRδ Locus in Murine Thymocytes segments (Tonegawa, 1983; Lewis and Gellert, 1989). These rearrangements are mediated by a recombination activity that recognizes signal sequences (consisting of conserved heptamer and nonamer elements separated by nonconserved spacer regions of 12 or 23 nucleotides) located adjacent to the V, D, a

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Replication, Transcription, CpG Methylation and DNA Topology in V(D)J Recombinationficity by unknown mechanisms. The physical basis for the differential accessibility in this site-specific recombination reaction has been a matter of much speculation. Possibilities have included the processes of transcription (Ferrier et al., 1989; Martin et al., 1991; Schlissel et al., 1991) and D

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Rearrangement and Expression of Immunoglobulin Genes in Transgenic Miceouse strain. When the transgene is bred into the C57BL/6 strain, it is completely methylated and not rearranged in lymphoid organs. After several generations of crossing into DBA/2 or SJL the transgene becomes unmethylated and rearranges at high frequency. A strain specific modifier of DNA methylati

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for a cost effective solution. In mobile ad hoc networks (MANETs), the function and location of the randomly connected mobile nodes keep on changing based on the user necessity. The seamless and longer duration network connectivity depends upon mainly on density of nodes, their mobility, speed, paus

landmark

F. Melchers,D. Haasner,H. Karasuyama,L. Reininger,A. Rolinke. Metabolites are the main working horses to drive for any phenotype as compared to their corresponding DNA or RNA component by itself alone. This omics tool integrated with mass spectrometric analysis can be applied to study the molecular responses in plants against biotic and abiotic stresses. Ch