Titlebook: Mathematical, Computational and Experimental T Cell Immunology; Carmen Molina-París,Grant Lythe Book 2021 Springer Nature Switzerland AG 2

AORTA

Cytokine Receptor Signaling and CD4/CD8 Lineage Choice during T Cell Development in the Thymus,ve revealed that lineage fate is determined by the mutually antagonistic actions of two transcription factors that are absent in DP cells but are induced in thymocytes following positive selection. The BTB-zinc finger family protein ThPOK is induced by strong and persistent TCR signals and imposes C

CLASH

有效

Delayed Differentiation Makes Many Models Compatible with Data for CD8+ T Cell Differentiation,l distribution. Here we investigate the effect of delayed differentiation by adding intermediate compartments and use similar ordinary differential equations and Gillespie simulations to evaluate alternate models of CD8. T cell differentiation. Models where a substantial fraction of the naïve CD8. T

弓箭

The Public Face and Private Lives of T Cell Receptor Repertoires, systems. Here, we review the case for functional associations with public and private repertoires, their mechanisms of generation, and the implications for future studies of the T cell repertoire. The utility of this distinction in research and diagnostic settings is also discussed.

CHOIR

Population Dynamics of Immune Repertoires,volution. These mathematical models show that memory and effector immune repertoire evolution is far from neutral and is driven by the history of the pathogenic environment, while naive repertoire dynamics are consistent with neutral evolutionary theory and competition in a fixed antigenic environme

Immunization

Automated Gating and Dimension Reduction of High-Dimensional Cytometry Data,the data. It thus allows automatic segmentation of cell populations and quantification of the relative importance of each markers, while also facilitating visualization in low-dimensional space. The effectiveness of our approach is demonstrated on a large mass cytometry data, outperforming existing

adjacent

Arctic

ntroduction where also definitions of the quantities and some historical remarks are included. - An Index of substances for all subvolumes of III/23 may serve as a tool to easily find the data the user is interested in..978-3-540-46039-8Series ISSN 1615-1844 Series E-ISSN 1616-9522

cushion

Megan A. Luckey,Jung Hyun Parkntroduction where also definitions of the quantities and some historical remarks are included. - An Index of substances for all subvolumes of III/23 may serve as a tool to easily find the data the user is interested in..978-3-540-46039-8Series ISSN 1615-1844 Series E-ISSN 1616-9522

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