Titlebook: Mathematical and Statistical Methods for Genetic Analysis; Kenneth Lange Textbook 2002Latest edition Springer Science+Business Media New Y

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Computation of Mendelian Likelihoods,vestigate efficient algorithms for likelihood computation on pedigree data, placing particular stress on the pioneering algorithm of Elston and Stewart 8. It is no accident that their research coincided with the introduction of modern computing. To analyze human pedigree data is tedious, if not impo

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Molecular Phylogeny,olecular genetics [17, 22, 23]. It is now relatively simple to sequence genes and to compare the results from several contemporary taxa. In the current chapter we will assume that the chore of aligning the DNA sequences from these taxa has been successfully accomplished. The taxa are then arranged i

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Radiation Hybrid Mapping,e of the irradiated cells by hybridization to rodent cells, and analyzing the hybrid cells for surviving fragments of a particular human chromosome. For various technical reasons, radiation hybrid mapping languished for nearly a decade and a half until revived by Cox et al. [10]. The current, more s

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Models of Recombination,ter pairs then perfectly align to form a bundle of four chromatids. Crossing-over occurs at points along the bundle known as .. At each ., one sister chromatid from each pair is randomly selected and cut at the crossover point. The cell then rejoins the partial paternal chromatid above the cut to th

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Sequence Analysis,minate the evolutionary history of the new gene and the structure and function of its derived protein. Indeed, it is fair to say that sequence comparison is the single most useful application of the burgeoning genetic databases. Cross species comparisons are being done on a massive scale to identify

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Poisson Approximation,a sum of weakly dependent Bernoulli random variables. In contrast to many asymptotic methods, this approximation carries with it explicit error bounds. Let .. be a Bernoulli random variable with success probability ., where α ranges over some finite index set ..

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Kenneth Langeed in Southern Russia, it has a historically large Jewish population in its demographic structure. A ravine on the outskirts of the city—Zmievskaya Balka—is the largest Holocaust site in post-Soviet Russia. The reconstruction of Holocaust history during the second occupation of Rostov-on-Don based m