| 书目名称 | Mathematical Modelling of the Cell Cycle Stress Response |
| 编辑 | Elahe Radmaneshfar |
| 视频video | |
| 概述 | Nominated as an outstanding Ph.D. thesis by the University of Aberdeen, UK.Includes the first computational model of the entire cell cycle and its interaction with the osmotic stress response network. |
| 丛书名称 | Springer Theses |
| 图书封面 |  |
| 描述 | The cell cycle is a sequence of biochemical events that are controlled by complex but robust molecular machinery. This enables cells to achieve accurate self-reproduction under a broad range of conditions. Environmental changes are transmitted by molecular signaling networks, which coordinate their actions with the cell cycle.. .This work presents the first description of two complementary computational models describing the influence of osmotic stress on the entire cell cycle of S. cerevisiae. Our models condense a vast amount of experimental evidence on the interaction of the cell cycle network components with the osmotic stress pathway. Importantly, it is only by considering the entire cell cycle that we are able to make a series of novel predictions which emerge from the coupling between the molecular components of different cell cycle phases.. .The model-based predictions are supported by experiments in S. cerevisiae and, moreover, have recently been observed in other eukaryotes. Furthermore our models reveal the mechanisms that emerge as a result of the interaction between the cell cycle and stress response networks.. |
| 出版日期 | Book 2014 |
| 关键词 | Accelerated Exit from Mitosis; Boolean Model of Cell Cycle Stress Response; Cell Cycle Stress Response |
| 版次 | 1 |
| doi | https://doi.org/10.1007/978-3-319-00744-1 |
| isbn_softcover | 978-3-319-34620-5 |
| isbn_ebook | 978-3-319-00744-1Series ISSN 2190-5053 Series E-ISSN 2190-5061 |
| issn_series | 2190-5053 |
| copyright | Springer International Publishing Switzerland 2014 |
发表于 2025-3-21 18:39:50
