Titlebook: Mass Spectrometry Imaging of Small Molecules; Methods and Protocol Young-Jin Lee Book 2022 The Editor(s) (if applicable) and The Author(s),

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Ambient Mass Spectrometry Imaging of Small Molecules from Cells and Tissuesy atmospheric plasma and nanomaterials such as nanoparticles and graphene to enhance laser ablation. The second one is based on secondary ion mass spectrometry (SIMS) imaging of live cells in solution capped with single-layer graphene to preserve intact and hydrated biological samples even under ultrahigh vacuum for SIMS bio-imaging in solution.

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1064-3745 ation advice from the experts.This volume presents updated methods and new developments in the field of mass spectrometry imaging. Chapters guide readers through four parts covering imaging, software,  data analysis, new instrumentation, and new methodological approaches. Written in the highly succe

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Gas-Phase Ion–Ion Reactions for Lipid Identification in Biological Tissue Sectionst of imaging mass spectrometry (IMS) workflows. This chapter presents a methodology for the preparation of biological tissue samples and the use of a hybrid mass spectrometer to perform gas-phase charge inversion ion/ion reactions for improved lipid identification. This gas-phase ion/ion reaction me

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Ambient Mass Spectrometry Imaging of Small Molecules from Cells and Tissuesis report. The first approach, an atmospheric pressure mass spectrometry imaging method, is based on laser ablation in atmospheric pressure assisted by atmospheric plasma and nanomaterials such as nanoparticles and graphene to enhance laser ablation. The second one is based on secondary ion mass spe

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Single-Cell Metabolomics with Rapid Determination of Chemical Formulas from Isotopic Fine Structureshat permits direct untargeted detection of a broad number of metabolites under ambient conditions, without the need for sample processing, and with high confidence in the discovery and identification of the molecular formulas for detected metabolites. This protocol describes combining fiber-based la

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TOF-SIMS Imaging of Biological Tissue Sections and Structural Determination Using Tandem MSging mass spectrometry allows for label-free chemical imaging by providing full molecular information. The IMS technique best positioned for cell and tissue analysis is time-of-flight secondary ion mass spectrometry (ToF-SIMS) because it has the best spatial resolution of all the molecular IMS techn

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Metal-Assisted Laser Desorption Ionization Imaging Mass Spectrometrye sections. However, traditional MALDI imaging mass spectrometry (IMS) suffers from low matrix homogeneity and high signal background in low mass range caused by matrix signals. To overcome these issues, alternative workflow and methods have been developed. Of these, metal-assisted laser desorption

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Mass Spectrometry Imaging of Metabolites by Nanostructure Initiator Mass Spectrometry with Fluorinatath of polar metabolites and lipids with high spatial resolution and ultrasensitivity. Here we describe the methods and procedures for the synthesis and application of f-AuNPs for NIMS of small molecule metabolites and lipids in biological tissues, encompassing sample preparation, mass spectrometric