Titlebook: Marek’s Disease; Scientific Basis and L. N. Payne Book 1985 Martinus Nijhoff Publishing, Boston 1985 diagnosis.oncology.pathology.vaccinati

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Laboratory Diagnosis, world. Highly successful vaccination programmes have dramatically reduced natural outbreaks of MD in commercial chickens. However, vaccination has not eradicated MD and outbreaks continue to occur sporadically, hence the need for proper diagnosis of the disease.

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Immunity,s are responsible for mounting immune responses, some of which may contribute to protection while others may be involved in the pathology of the disease, and it is the same cell type that is the primary target for infection with Marek’s disease virus (MDV). Infection may be lytic, resulting in cell

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Principles of Vaccination,main means by which the disease can be controlled. The first practical vaccine for MD was developed by Churchill .. (1) and consisted of an attenuated serotype 1 MD virus (MDV). This development followed shortly the isolation of the causative herpesvirus of MD and its propagation in tissue culture.

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Genetic Resistance,ce of the disease differed amongst families (1–4). In 1935, Hutt and Cole (5) initiated their classic studies which were to prove that selection for genetic resistance could constitute a practical method for the control of disease in poultry flocks. Two resistant strains, K and C, and one susceptibl

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