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Titlebook: Marburg Virus Disease; Gustav Adolf Martini (Direktor),Rudolf Siegert (Di Book 1971 Springer-Verlag Berlin Heidelberg 1971 antibody.cell.c

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发表于 2025-3-21 17:14:55 | 显示全部楼层 |阅读模式
书目名称Marburg Virus Disease
编辑Gustav Adolf Martini (Direktor),Rudolf Siegert (Di
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图书封面Titlebook: Marburg Virus Disease;  Gustav Adolf Martini (Direktor),Rudolf Siegert (Di Book 1971 Springer-Verlag Berlin Heidelberg 1971 antibody.cell.c
描述In the late summer of 1967, several patients suffering from a severe disease were admitted to the Department of Medicine of the Marburg University. It soon became obvious that the illness was a hitherto unknown infectious disease. The number of afflicted patients increased to 23. Several cases were observed in Frankfurt/Main at the same time and, some weeks later also in Belgrade, Yugo­ slavia. Common to all the patients was previous contact with the blood or tissues of Cercopithecus aethiops, the vervet monkey. Altogether 31 people became ill and 7 died. It was soon apparent that the infectious agent was neither bacterial nor rickettsial in origin but that a viral etiology was probable. Most of the known viral diseases were excluded and the infectious agent was shown to be a hitherto unknown virus with many peculiar characteristics: it infects guinea pigs but not adult mice and is larger than known viruses and of different shape. This agent was called the "Marburg virus" since most of the cases had occurred in Marburg and the greater part of the laboratory work leading to the detection of the virus was performed in Marburg.
出版日期Book 1971
关键词antibody; cell; cell culture; hepatitis; infection; infectious disease; pathogenesis; vaccine; virus
版次1
doihttps://doi.org/10.1007/978-3-662-01593-3
isbn_softcover978-3-662-01595-7
isbn_ebook978-3-662-01593-3
copyrightSpringer-Verlag Berlin Heidelberg 1971
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Marburg Virus Disease. Clinical Syndrome,for pharmacological and physiological experiments. Since it has turned out that kidney cells of monkeys are very convenient for breeding pathogenous viruses, millions of monkeys were needed by virological institutes and pharmaceutic firms throughout the world. As the animals are transported by air d
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Clinical Manifestations and Mechanism of the Haemorrhagic Diathesis in Marburg Virus Disease,rhages from the mucosa of the mouth and nose, as well as of the whole intestinal tract. In some cases petechial bleedings of varying severity were also observed in the skin. In most patients protracted bleeding from injection areas of the skin was noticed.
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Biological Properties of the Marburg Virus,11, 12, 13, 18], and suckling mice [7], in primary and continuous cell lines of various origin [1, 2, 5, 6, 7, 9, 10, 11, 13, 16, 18, 19, 20], and in insects [8]. However, in adult mice [7] and in the fetal organs of chick-embryos [18, 11] no multiplication of virus could be detected. Susceptibility
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Cultivation of the Marburg Virus (Rhabdovirus simiae) in Cell Cultures,tion purposes laboratory animals and many cell systems were employed but all initial trials in cell cultures were unsuccessful (. et al., 1967; . and ., 1968; . et al., 1968). Later when the virus was isolated in guinea pigs (. et al., 1967; . et al., 1967; . et al., 1968; . and ., 1968; . et al., 1
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