Titlebook: Manufacturing Civil Society; Principles, Practice Taco Brandsen (Professor of Comparative Public Adm Book 2014 Palgrave Macmillan, a divisi

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Taco Brandsen,Bram Verschuere,Willem Trommelir biological relevance.Written by experts in the field.Incl.Matrix metalloproteinases (MMPs) are proteolytic enzymes that are involved in many physiological and pathological processes. The field of MMP research is very important due to the implications of the distinct paralogs in both human physiol

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Rik Peetersstant sites. The “three step theory of invasion” proposed by Liotta and colleagues . suggests that potentially invasive cells must first attach to basement membrane proteins via cell-surface receptors, i.e., the integrins. Localized, extracellular proteolytic activity then clears a path for the cell

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Jenny Harlockstasis, growth, and angiogenesis. Thus there is considerable interest in the design of MMP inhibitors (MMPIs) . as they promise to provide a novel noncytotoxic means of treating human cancer. Furthermore, pharmacological studies of MMPIs in animal models of human disease suggest that the potential t

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Rory Shand,Roger Higman proteins are not sufficiently abundant in their natural state to be used as the primary source, and so it is essential for recombinant protein to be expressed in an appropriate system. In many cases the preferred expression system is . for ease of handling, generally high yields and, where the prot

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Annelie Beller,Rabea Haßogenous protein inhibitors, the tissue inhibitors of metalloproteinases (TIMPs). Disruption of this balance results in serious diseases such as arthritis and tumor growth and metastasis. Knowledge of the tertiary structures of the proteins involved is crucial for understanding their functional prope

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Simona Franzonimatrix (ECM). The role that the MMPs play in normal and pathological conditions has long been of interest. The mechanisms by which the MMPs cleave the different components of the ECM have been examined extensively. Some of these studies have been made possible, in part, by the ability to express rec