Titlebook: Manual of Biological Markers of Disease; W. J. Venrooij,R. N. Maini Book 1996 Springer Science+Business Media Dordrecht 1996 Antigen.Labor

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Immunoprecipitation of labelled proteinsre components of subcellular particles (for review see [1]). These subcellular particles frequently comprise aggregates of several different proteins, with or without different species of RNA. Specific immunoprecipitation using a defined autoantibody, therefore results in the precipitation of not on

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Analysis of autoimmune sera by immunoprecipitation of cellular RNPss of cytoplasmic and nuclear ribonucleoprotein (RNP) particles (reviewed in [1]). Patients with systemic lupus erythematosus (SLE), mixed connective tissue disease (MCTD) and Sjögren’s syndrome often develop antibodies against the snRNP, Ro and La ribonucleoprotein particles, respectively (Table 1).

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Measurement of antibodies to DNAs disease, which makes their detection an important diagnostic aid to the clinician. Fluctuations in the level of anti-dsDNA in an individual patient generally parallel the clinical status of that patient. Furthermore, the presence of anti-dsDNA may precede the diagnosis of SLE by more than a year.

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DNA as antigen in SLEr single-stranded (ssDNA); the influence of DNA strands will be further discussed in paragraph 14. Furthermore, DNA as antigen will . almost always occur in the form of nucleosomes, i.e. closely associated with histones.

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mechanical

Scleroderma-associated antigensrologic markers have been shown to be useful in diagnosis and identifying disease subsets [3–5]. A number of autoantigens in scleroderma have been described. The most important are: DNA topoisomerase I (110 kDa) [3, see also this Manual, chapter B-5.1], the centromere proteins CENP-A (17 kDa), CENP-